Evidence map›Paper›PMID 34209734›Full record

ReviewBiomolecules2021

Meroterpenoids: A Comprehensive Update Insight on Structural Diversity and Biology.

Mamona Nazir, Muhammad Saleem, Muhammad Imran Tousif, Muhammad Aijaz Anwar, Frank Surup, Iftikhar Ali, Daijie Wang, Nilufar Z Mamadalieva, Elham Alshammari, Mohamed L Ashour and 5 more

Abstract readReview
In one paragraph

Review in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed.

  1. Article
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  5. Global profiling of polyketide synthases in facultative multicellular eukaryotes.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Review
  7. Enantioselective Total Synthesis of (-)-Psiguadial A.Angewandte Chemie (International ed. in English) · 2025
    Article
  8. Article
  9. Characterization of the Antiproliferative and Antimetastatic Properties ofInternational journal of molecular sciences · 2025
    Article
  10. Review
  11. Review
  12. IMA fungus · 2025
    Review
  13. Article
  14. Review
  15. Article
  16. Understanding metabolic diversification in plants: branchpoints in the evolution of specialized metabolism.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Review
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Mamona NazirDepartment of Chemistry, Government Sadiq College Women University Bahawalpur, Bahawalpur 63100, Pakistan.
Muhammad SaleemInstitute of Chemistry, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan.ORCID 0000-0001-7704-1087
Muhammad Imran TousifDepartment of Chemistry, DG Khan Campus, University of Education Lahore, Dera Ghazi Khan 32200, Pakistan.ORCID 0000-0002-5777-6112
Muhammad Aijaz AnwarPharmaceutical Research Division, PCSIR Laboratories Complex Karachi, Karachi 75280, Pakistan.
Frank SurupMicrobial Drugs, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany.ORCID 0000-0001-5234-8525
Iftikhar AliSchool of Pharmaceutical Sciences and Key Laboratory for Applied Technology of Sophisticated Analytical Instruments of Shandong Province, Shandong Analysis and Test Center, School of Pharmaceutical Sciences, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China.ORCID 0000-0002-5817-8800
Daijie WangSchool of Pharmaceutical Sciences and Key Laboratory for Applied Technology of Sophisticated Analytical Instruments of Shandong Province, Shandong Analysis and Test Center, School of Pharmaceutical Sciences, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China.
Nilufar Z MamadalievaDepartment of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, D-06120 Halle, Germany.ORCID 0000-0003-1756-3638
Elham AlshammariDepartment of Pharmacy Practice, College of Pharmacy, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi Arabia.ORCID 0000-0002-8637-9618
Mohamed L AshourDepartment of Pharmaceutical Sciences, Pharmacy Program, Batterjee Medical College, Jeddah 21442, Saudi Arabia.ORCID 0000-0002-9270-6267
Ahmed M AshourDepartment of Pharmacology and Toxicology, College of Pharmacy, Umm Al-Qura University, P.O. Box 13578, Makkah 21955, Saudi Arabia.ORCID 0000-0002-2118-0499
Ishtiaq AhmedDepartment of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB2 1TN, UK.
ElizbitDepartment of Materials Engineering, National University of Sciences and Technology (NUST) H12, Islamabad 44000, Pakistan.
Ivan R GreenDepartment of Chemistry and Polymer Science, University of Stellenbosch, Private Bag X1, Matieland, Stellenbosch 7600, South Africa.ORCID 0000-0002-9158-670X
Hidayat HussainDepartment of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, D-06120 Halle, Germany.ORCID 0000-0002-8654-8127

Funding

This research was funded by the Deanship of Scientific Research at Princess Nourah bint Abdulrahman University through the Fast-track Research Funding Program
6 · The paper itself

Abstract

Meroterpenoids are secondary metabolites formed due to mixed biosynthetic pathways which are produced in part from a terpenoid co-substrate. These mixed biosynthetically hybrid compounds are widely produced by bacteria, algae, plants, and animals. Notably amazing chemical diversity is generated among meroterpenoids via a combination of terpenoid scaffolds with polyketides, alkaloids, phenols, and amino acids. This review deals with the isolation, chemical diversity, and biological effects of 452 new meroterpenoids reported from natural sources from January 2016 to December 2020. Most of the meroterpenoids possess antimicrobial, cytotoxic, antioxidant, anti-inflammatory, antiviral, enzyme inhibitory, and immunosupressive effects.

Indexed as

AlkaloidsAnimalsAnti-Bacterial AgentsAnti-Infective AgentsAntineoplastic AgentsAntioxidantsBacteriaBenzopyransBenzoquinonesBiological ProductsBiosynthetic PathwaysFungiHumansSecondary MetabolismSesquiterpenesTerpenesAlkaloidsAnti-Bacterial AgentsAnti-Infective AgentsAntineoplastic AgentsAntioxidantsBenzopyransBenzoquinonesBiological ProductsquinoneSesquiterpenesTerpenesanticancerantidiabeticanti-inflammatoryantioxidantmeroterpenoidsstructural diversity

Identifiers

PMID34209734
PMCPMC8301922

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.