Evidence map›Paper›PMID 34209709›Full record

ArticleJournal of personalized medicine2021

The Impact of Marijuana on Antidepressant Treatment in Adolescents: Clinical and Pharmacologic Considerations.

Samuel E Vaughn, Jeffrey R Strawn, Ethan A Poweleit, Mayur Sarangdhar, Laura B Ramsey

Open access · goldAbstract read
In one paragraph

Article in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 38 citations in OpenAlex.

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  6. Comorbid Cannabis Use and Mood Disorders Among Adolescents.Focus (American Psychiatric Publishing) · 2025
    Review
  7. Cannabis, cannabinoids and health: a review of evidence on risks and medical benefits.European archives of psychiatry and clinical neuroscience · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Samuel E VaughnDivision of Child and Adolescent Psychiatry, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, College of Medicine, University of Cincinnati, Cincinnati, OH 45229, USA.
Jeffrey R StrawnDivision of Child and Adolescent Psychiatry, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, College of Medicine, University of Cincinnati, Cincinnati, OH 45229, USA.
Ethan A PoweleitDivision of Biomedical Informatics, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, College of Medicine, University of Cincinnati, Cincinnati, OH 45229, USA.
Mayur SarangdharDivision of Biomedical Informatics, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, College of Medicine, University of Cincinnati, Cincinnati, OH 45229, USA.
Laura B RamseyDivision of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, College of Medicine, University of Cincinnati, Cincinnati, OH 45229, USA.ORCID 0000-0001-6417-3961
Cincinnati Children's Hospital Medical Center · US

Funding

Improving the Effectiveness and Safety of Escitalopram in Pediatric Anxiety Disorders Using Pharmacogenetically-guided DosingR01HD099775 · NICHD · UNIVERSITY OF CINCINNATI · PI RAMSEY, LAURA B, STRAWN, JEFFREY ROBERT · 2020 to 2024
$2.9M
Estracellular Vesicles as Non-Invasive Predictors of Antidepressant Outcomes in Pediatric AnxietyR01HD098757 · NICHD · UNIVERSITY OF CINCINNATI · PI STRAWN, JEFFREY ROBERT · 2019 to 2024
$2.4M
Eunice Kennedy Shriver National Institute of Child Health and Human Development HD099775NICHD NIH HHS R01 HD098757NICHD NIH HHS R01 HD099775
6 · The paper itself

Abstract

The neuropharmacology of marijuana, including its effects on selective serotonin reuptake inhibitor (SSRI)/antidepressant metabolism and the subsequent response and tolerability in youth, has received limited attention. We sought to (1) review clinically relevant pharmacokinetic (PK) and pharmacodynamic (PD) interactions between cannabinoids and selected SSRIs, (2) use PK models to examine the impact of cannabinoids on SSRI exposure (area under curve (AUC)) and maximum concentration (C

Indexed as

adverse reactionsCYP2C19drug–drug interactionmarijuanaselective serotonin reuptake inhibitors

Identifiers

PMID34209709
PMCPMC8307883
OpenAlexW3174116238

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.