ArticleJournal of clinical medicine2021
Effect of Upper Airway Stimulation in Patients with Obstructive Sleep Apnea (EFFECT): A Randomized Controlled Crossover Trial.
Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Patient-reported outcomes with hypoglossal nerve stimulation for treatment of obstructive sleep apnea: a systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023Pooled it
- Proximal Hypoglossal Nerve Stimulation for Obstructive Sleep Apnea in the OSPREY Study : A Randomized Controlled Trial.Annals of internal medicine · 2026Trial
- Metabolic assessments of neurostimulation therapy to reduce apnea (MANTRA) trial: rationale and methods.Sleep & breathing = Schlaf & Atmung · 2026Trial
- Article
- Changes in the apnea index to hypopnea index ratio after upper airway stimulation therapy.Sleep & breathing = Schlaf & Atmung · 2026Article
- Hypoglossal Nerve Stimulation Therapy in a Belgian Cohort of Obstructive Sleep Apnea Patients.Life (Basel, Switzerland) · 2024Article
- Use of Hypoglossal Nerve Stimulation for Treating OSA in Military Patient Populations.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2024Review
- The effect of velar collapse patterns on unilateral upper airway stimulation therapy.Sleep & breathing = Schlaf & Atmung · 2024Article
- The Role of Transoral Robotic Surgery in the Era of Hypoglossal Nerve Stimulation.Journal of clinical medicine · 2023Article
- Translation of obstructive sleep apnea pathophysiology and phenotypes to personalized treatment: a narrative review.Frontiers in neurology · 2023Review
- Quality of Life Impact of Hypoglossal Nerve Stimulation with InspireLife (Basel, Switzerland) · 2022Article
- Design and rationale for the treating Obstructive Sleep Apnea using Targeted Hypoglossal Nerve Stimulation (OSPREY) trial.Contemporary clinical trials · 2022Article
- [Morphological changes of upper airway in patients with obstructive sleep apnea hypopnea syndrome after H-UPPP].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2022Article
- Hypoglossal nerve stimulation for obstructive sleep apnea: updated position paper of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022Review
- Hypoglossal Nerve Stimulation Therapy.Advances in experimental medicine and biology · 2022Article
- Obstructive Sleep Apnoea: Focus on Pathophysiology.Advances in experimental medicine and biology · 2022Article
- The hidden magic of hypoglossal nerve stimulation therapy: organizing the sleep surgery research community.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeveral single-arm prospective studies have demonstrated the safety and effectiveness of upper airway stimulation (UAS) for obstructive sleep apnea. There is limited evidence from randomized, controlled trials of the therapy benefit in terms of OSA burden and its symptoms.
methodsWe conducted a multicenter, double-blinded, randomized, sham-controlled, crossover trial to examine the effect of therapeutic stimulation (
resultsThe study randomized 89 participants 1:1 to
conclusionsIn comparison with sham stimulation, therapeutic UAS reduced OSA severity, sleepiness symptoms, and improved quality of life among participants with moderate-to-severe OSA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.