Evidence map›Paper›PMID 34209567›Full record

ArticleNutrients2021

Protective Effects of Collagen Tripeptides in Human Aortic Endothelial Cells by Restoring ROS-Induced Transcriptional Repression.

Hidehito Saito-Takatsuji, Yasuo Yoshitomi, Yasuhito Ishigaki, Shoko Yamamoto, Noriaki Numata, Yasuo Sakai, Masayoshi Takeuchi, Naohisa Tomosugi, Shogo Katsuda, Hideto Yonekura and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Targeting collagen to optimize cancer immunotherapy.Experimental hematology & oncology · 2025
    Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Hidehito Saito-TakatsujiDepartment of Biochemistry, Kanazawa Medical University School of Medicine, 1-1 Daigaku, Uchinada, Kahoku-gun, Ishikawa 920-0293, Japan.
Yasuo YoshitomiDepartment of Biochemistry, Kanazawa Medical University School of Medicine, 1-1 Daigaku, Uchinada, Kahoku-gun, Ishikawa 920-0293, Japan.ORCID 0000-0002-9935-5324
Yasuhito IshigakiDivision of Molecular Oncology and Virology, Department of Life Science, Medical Research Institute, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Kahoku, Ishikawa 920-0293, Japan.ORCID 0000-0003-1012-8430
Shoko YamamotoTechnical Center, Jellice Co., Ltd., 4-4-1 Sakae, Tagajo, Miyagi 985-0833, Japan.
Noriaki NumataTechnical Center, Jellice Co., Ltd., 4-4-1 Sakae, Tagajo, Miyagi 985-0833, Japan.
Yasuo SakaiTechnical Center, Jellice Co., Ltd., 4-4-1 Sakae, Tagajo, Miyagi 985-0833, Japan.
Masayoshi TakeuchiDivision of AGEs Research, Department of Advanced Medicine, Medical Research Institute, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Kahoku, Ishikawa 920-0293, Japan.ORCID 0000-0002-1057-3764
Naohisa TomosugiDivision of Aging Research, Department of Advanced Medicine, Medical Research Institute, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Kahoku, Ishikawa 920-0293, Japan.
Shogo KatsudaDepartment of Pathology II, Kanazawa Medical University School of Medicine, 1-1 Daigaku, Uchinada, Kahoku-gun, Ishikawa 920-0293, Japan.
Hideto YonekuraDepartment of Biochemistry, Kanazawa Medical University School of Medicine, 1-1 Daigaku, Uchinada, Kahoku-gun, Ishikawa 920-0293, Japan.
Takayuki IkedaDepartment of Biochemistry, Kanazawa Medical University School of Medicine, 1-1 Daigaku, Uchinada, Kahoku-gun, Ishikawa 920-0293, Japan.ORCID 0000-0001-9546-2248
Kanazawa Medical University · JP

Funding

Ministry of Economy, Trade and Industry of Japan 23220419002
6 · The paper itself

Abstract

Collagen tripeptide (CTP) is defined as a functional food material derived from collagenase digests of type I collagen and contains a high concentration of tripeptides with a Gly-X-Y sequence. CTP has several biological effects, including the acceleration of fracture healing, ameliorating osteoarthritis, and improving dryness and photoaging of the skin. Recently, an antiatherosclerotic effect of CTP has been reported, although its molecular mechanism is yet to be determined. In this study, we examined the effects of CTP on primary cultured human aortic endothelial cells (HAECs) under oxidative stress, because oxidative endothelial dysfunction is a trigger of atherosclerosis. DNA microarray and RT-qPCR analyses showed that CTP treatment recovered the downregulated expression of several genes, including the interleukin-3 receptor subunit alpha (

Indexed as

AortaAtherosclerosisCell LineCells, CulturedCell SurvivalCollagen Type IDown-RegulationEndothelial CellsFunctional FoodHumansInterleukin-3 Receptor alpha SubunitOsteoblastsOxidative StressPeptide Transporter 1Protective AgentsReactive Oxygen Speciescollagen tripeptide Ctp, humanCollagen Type IIL3RA protein, humanInterleukin-3 Receptor alpha SubunitPeptide Transporter 1Protective AgentsReactive Oxygen SpeciesSLC15A1 protein, humancollagen tripeptidegene expressionhuman aortic endothelial cellsoxidative stress

Identifiers

PMID34209567
PMCPMC8308296
OpenAlexW3177483081

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.