Microfluidic Obstacle Arrays Induce Large Reversible Shape Change in Red Blood Cells.

David W Inglis, Robert E Nordon, Jason P Beech, Gary Rosengarten

Abstract read

In one paragraph

Article in Micromachines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

David W InglisSchool of Engineering, Macquarie University, Sydney, NSW 2109, Australia.ORCID 0000-0001-8239-5568

Robert E NordonGraduate School of Biomedical Engineering, University of New South Wales Sydney, Sydney, NSW 2052, Australia.

Jason P BeechDivision of Solid State Physics and NanoLund, Physics Department, Lund University, P.O. Box 118, 22100 Lund, Sweden.ORCID 0000-0002-1347-4657

Gary RosengartenSchool of Engineering, RMIT University, Melbourne, VIC 3053, Australia.

Funding

Australian Research Council DP110102207

6 · The paper itself

Abstract

Red blood cell (RBC) shape change under static and dynamic shear stress has been a source of interest for at least 50 years. High-speed time-lapse microscopy was used to observe the rate of deformation and relaxation when RBCs are subjected to periodic shear stress and deformation forces as they pass through an obstacle. We show that red blood cells are reversibly deformed and take on characteristic shapes not previously seen in physiological buffers when the maximum shear stress was between 2.2 and 25 Pa (strain rate 2200 to 25,000 s

Indexed as

deterministic lateral displacementDLDerythrocytemicrofluidicmorphologyshear

Identifiers

PMID34209413

DOI10.3390/mi12070783

PMCPMC8303182

What OpenQuestion holds

Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.