Evidence map›Paper›PMID 34209365›Full record

ArticleInternational journal of molecular sciences2021

Synergistic Effect of the Long-Term Overexpression of Bcl-2 and BDNF Lentiviral in Cell Protecting against Death and Generating TH Positive and CHAT Positive Cells from MSC.

Paulina Borkowska, Aleksandra Zielinska, Monika Paul-Samojedny, Rafał Stojko, Jan Kowalski

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Mesenchymal Stem Cells: Therapeutic Mechanisms for Stroke.International journal of molecular sciences · 2022
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Paulina BorkowskaDepartment of Medical Genetics, Medical University of Silesia, 41-200 Sosnowiec, Poland.ORCID 0000-0003-3150-3084
Aleksandra ZielinskaDepartment of Medical Genetics, Medical University of Silesia, 41-200 Sosnowiec, Poland.
Monika Paul-SamojednyDepartment of Medical Genetics, Medical University of Silesia, 41-200 Sosnowiec, Poland.
Rafał StojkoChair and Department of Gynecology, Obstetrics and Oncological Gynecology, Medical University of Silesia, 40-211 Katowice, Poland.ORCID 0000-0002-5141-1016
Jan KowalskiDepartment of Medical Genetics, Medical University of Silesia, 41-200 Sosnowiec, Poland.
Medical University of Silesia · PL

Funding

Śląski Uniwersytet Medyczny PCN-1-056/N/0/B
6 · The paper itself

Abstract

Mesenchymal stem cells (MSC) are potentially a good material for transplantation in many diseases, including neurodegenerative diseases. The main problem with using them is the low percentage of surviving cells after the transplant procedure and the naturally poor ability of MSC to spontaneously differentiate into certain types of cells, which results in their poor integration with the host cells. The aim and the novelty of this work consists in the synergistic overexpression of two genes,

Indexed as

Cell DifferentiationBrain-Derived Neurotrophic FactorDopaminergic NeuronsHumansLentivirusMesenchymal Stem CellsProto-Oncogene Proteins c-bcl-2Transduction, GeneticBCL2 protein, humanBDNF protein, humanBrain-Derived Neurotrophic FactorProto-Oncogene Proteins c-bcl-2Bcl-2BDNFcholinergic neuronsdifferentiationdopaminergic neuronslentiviral transductionmesenchymal stem cells

Identifiers

PMID34209365
PMCPMC8268627
OpenAlexW3176750678

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.