Evidence map›Paper›PMID 34209299›Full record

ArticleInternational journal of molecular sciences2021

The Involvement of Insulin-Like Growth Factor 1 and Nerve Growth Factor in Alzheimer's Disease-Like Pathology and Survival Role of the Mix of Embryonic Proteoglycans: Electrophysiological Fingerprint, Structural Changes and Regulatory Effects on Neurotrophins.

Michail Aghajanov, Senik Matinyan, Vergine Chavushyan, Margarita Danielyan, Gohar Karapetyan, Margarita Mirumyan, Katarine Fereshetyan, Hayk Harutyunyan, Konstantin Yenkoyan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Experimental modeling of Alzheimer's disease: Translational lessons from cross-taxon analyses.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Michail AghajanovDepartment of Biochemistry, Yerevan State Medical University after M. Heratsi, Yerevan 0025, Armenia.
Senik MatinyanDepartment of Biochemistry, Yerevan State Medical University after M. Heratsi, Yerevan 0025, Armenia.ORCID 0000-0002-3304-0389
Vergine ChavushyanLaboratory of Neuroscience, Yerevan State Medical University after M.Heratsi, Yerevan 0025, Armenia.
Margarita DanielyanLaboratory of Neuroscience, Yerevan State Medical University after M.Heratsi, Yerevan 0025, Armenia.ORCID 0000-0001-8334-7066
Gohar KarapetyanLaboratory of Neuroscience, Yerevan State Medical University after M.Heratsi, Yerevan 0025, Armenia.
Margarita MirumyanDepartment of Biochemistry, Yerevan State Medical University after M. Heratsi, Yerevan 0025, Armenia.
Katarine FereshetyanDepartment of Biochemistry, Yerevan State Medical University after M. Heratsi, Yerevan 0025, Armenia.
Hayk HarutyunyanDepartment of Biochemistry, Yerevan State Medical University after M. Heratsi, Yerevan 0025, Armenia.
Konstantin YenkoyanDepartment of Biochemistry, Yerevan State Medical University after M. Heratsi, Yerevan 0025, Armenia.
Yerevan State Medical University · AML. A. Orbeli Institute of Physiology NAS RA · AM

Funding

Horizon 2020 Framework Programme 857600State Committee of Science 20TTCG-3A012State Committee of Science N 10-14/I-1
6 · The paper itself

Abstract

Alzheimer's disease (AD)-associated neurodegeneration is triggered by different fragments of amyloid beta (Aβ). Among them, Aβ (25-35) fragment plays a critical role in the development of neurodegeneration-it reduces synaptic integrity by disruption of excitatory/inhibitory ratio across networks and alters the growth factors synthesis. Thus, in this study, we aimed to identify the involvement of neurotrophic factors-the insulin-like growth factor 1 (IGF-1) and nerve growth factor (NGF)-of AD-like neurodegeneration induced by Aβ (25-35). Taking into account our previous findings on the neuroprotective effects of the mix of proteoglycans of embryonic genesis (PEG), it was suggested to test its regulatory effect on IGF-1 and NGF levels. To evaluate the progress of neurodegeneration, in vivo electrophysiological investigation of synaptic activity disruption of the entorhinal cortex

Indexed as

Alzheimer DiseaseBrainElectrocardiographyAmyloid beta-PeptidesAnimalsInsulin-Like Growth Factor IMaleNerve Growth FactorPeptide FragmentsRatsRats, Sprague-DawleyAmyloid beta-Peptidesamyloid beta-protein (25-35)insulin-like growth factor-1, ratInsulin-Like Growth Factor INerve Growth FactorNgf protein, ratPeptide Fragmentsamyloid-beta (25-35)hippocampusIGF-1NGFproteoglycans of embryonic genesis (PEG)

Identifiers

PMID34209299
PMCPMC8267974
OpenAlexW3174917477

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.