Evidence map›Paper›PMID 34209295›Full record

ArticleViruses2021

Serological Evidence of Filovirus Infection in Nonhuman Primates in Zambia.

Katendi Changula, Edgar Simulundu, Boniface Pongombo Lombe, Eri Nakayama, Hiroko Miyamoto, Yuji Takahashi, Hirofumi Sawa, Chuma Simukonda, Bernard M Hang'ombe, Ayato Takada

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Review
  6. Detection of anti-ebolavirus antibodies in Ghanaian pigs.The Journal of veterinary medical science · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Katendi ChangulaDepartment of Paraclinical Studies, School of Veterinary Medicine, University of Zambia, Lusaka 10101, Zambia.ORCID 0000-0003-2182-4319
Edgar SimulunduDepartment of Disease Control, School of Veterinary Medicine, University of Zambia, Lusaka 10101, Zambia.ORCID 0000-0001-9423-0816
Boniface Pongombo LombeDivision of Global Epidemiology, International Institute for Zoonosis Control, Hokkaido University, Sapporo 001-0020, Japan.
Eri NakayamaDepartment of Virology I, National Institute of Infectious Diseases, Tokyo 162-0052, Japan.ORCID 0000-0002-0826-3513
Hiroko MiyamotoDivision of Global Epidemiology, International Institute for Zoonosis Control, Hokkaido University, Sapporo 001-0020, Japan.
Yuji TakahashiDivision of Global Epidemiology, International Institute for Zoonosis Control, Hokkaido University, Sapporo 001-0020, Japan.
Hirofumi SawaDepartment of Disease Control, School of Veterinary Medicine, University of Zambia, Lusaka 10101, Zambia.
Chuma SimukondaDepartment of National Parks and Wildlife, Chilanga 10101, Zambia.
Bernard M Hang'ombeDepartment of Paraclinical Studies, School of Veterinary Medicine, University of Zambia, Lusaka 10101, Zambia.
Ayato TakadaDepartment of Disease Control, School of Veterinary Medicine, University of Zambia, Lusaka 10101, Zambia.ORCID 0000-0003-2464-6642
Hokkaido University · JPUniversity of Zambia · ZMNational Institute of Infectious Diseases · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ebolaviruses and marburgviruses are filoviruses that are known to cause severe hemorrhagic fever in humans and nonhuman primates (NHPs). While some bat species are suspected to be natural reservoirs of these filoviruses, wild NHPs often act as intermediate hosts for viral transmission to humans. Using an enzyme-linked immunosorbent assay, we screened two NHP species, wild baboons and vervet monkeys captured in Zambia, for their serum IgG antibodies specific to the envelope glycoproteins of filoviruses. From 243 samples tested, 39 NHPs (16%) were found to be seropositive either for ebolaviruses or marburgviruses with endpoint antibody titers ranging from 100 to 25,600. Interestingly, antibodies reactive to Reston virus, which is found only in Asia, were detected in both NHP species. There was a significant difference in the seropositivity for the marburgvirus antigen between the two NHP species, with baboons having a higher positive rate. These results suggest that wild NHPs in Zambia might be nonlethally exposed to these filoviruses, and this emphasizes the need for continuous monitoring of filovirus infection in wild animals to better understand the ecology of filoviruses and to assess potential risks of outbreaks in humans in previously nonendemic countries.

Indexed as

AnimalsAnimals, WildAntibodies, ViralChlorocebus aethiopsEbolavirusEnzyme-Linked Immunosorbent AssayFemaleFiloviridaeFiloviridae InfectionsHumansImmunoglobulin GMaleMarburgvirusPapioPrimatesSeroepidemiologic StudiesAntibodies, ViralImmunoglobulin GantibodyebolavirusEbola virusfilovirusmarburgvirusMarburg virusnonhuman primateseroprevalenceZambia

Identifiers

PMID34209295
PMCPMC8309988
OpenAlexW3176007920

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.