Evidence map›Paper›PMID 34209248›Full record

ArticleInternational journal of molecular sciences2021

Design, Synthesis, In Silico and In Vitro Studies for New Nitric Oxide-Releasing Indomethacin Derivatives with 1,3,4-oxadiazole-2-thiol Scaffold.

Alexandru Sava, Frederic Buron, Sylvain Routier, Alina Panainte, Nela Bibire, Sandra Mădălina Constantin, Florentina Geanina Lupașcu, Alin Viorel Focșa, Lenuţa Profire

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Trifluoromethylation of alkyl electrophiles withScience (New York, N.Y.) · 2025
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  3. Article
  4. In Vitro and In Silico Activities ofMolecules (Basel, Switzerland) · 2023
    Article
  5. Article
  6. Bioactive Oxadiazoles 2.0.International journal of molecular sciences · 2022
    Article
  7. Anti-Inflammatory Effects ofEvidence-based complementary and alternative medicine : eCAM · 2022
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Alexandru SavaDepartment of Analytical Chemistry, Faculty of Pharmacy, "Grigore T. Popa" University of Medicine and Pharmacy of Iași, 16 University Street, 700115 Iasi, Romania.ORCID 0000-0002-2759-4860
Frederic BuronInstitut de Chimie Organique et Analytique ICOA, CNRS UMR 7311, Université d'Orléans, 45067 Orléans, France.ORCID 0000-0001-5773-1515
Sylvain RoutierInstitut de Chimie Organique et Analytique ICOA, CNRS UMR 7311, Université d'Orléans, 45067 Orléans, France.
Alina PanainteDepartment of Analytical Chemistry, Faculty of Pharmacy, "Grigore T. Popa" University of Medicine and Pharmacy of Iași, 16 University Street, 700115 Iasi, Romania.
Nela BibireDepartment of Analytical Chemistry, Faculty of Pharmacy, "Grigore T. Popa" University of Medicine and Pharmacy of Iași, 16 University Street, 700115 Iasi, Romania.
Sandra Mădălina ConstantinDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, "Grigore T. Popa" University of Medicine and Pharmacy of Iași, 16 University Street, 700115 Iasi, Romania.
Florentina Geanina LupașcuDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, "Grigore T. Popa" University of Medicine and Pharmacy of Iași, 16 University Street, 700115 Iasi, Romania.
Alin Viorel FocșaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, "Grigore T. Popa" University of Medicine and Pharmacy of Iași, 16 University Street, 700115 Iasi, Romania.
Lenuţa ProfireDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, "Grigore T. Popa" University of Medicine and Pharmacy of Iași, 16 University Street, 700115 Iasi, Romania.ORCID 0000-0002-7953-3023
Grigore T. Popa University of Medicine and Pharmacy · ROUniversité d'Orléans · FR

Funding

AUF-IFA 28/2019CHembio FEDER-FSE 2014-2020-EX003677 EX003677FEDER under projects Valbiocosm FEDER-FSE 2017-EX003202IRON ANR-11-LABX-0018-01Techsab FEDER-FSE 2014-2020-EX011313 EX011313the SFR neuroimagerie (SFR FED 4224), the Labex programs SYNORG ANR-11-LABX-0029University of Medicine and Pharmacy "Grigore T. Popa" of Iasi 6985/2020
6 · The paper itself

Abstract

Starting from indomethacin (IND), one of the most prescribed non-steroidal anti-inflammatory drugs (NSAIDs), new nitric oxide-releasing indomethacin derivatives with 1,3,4-oxadiazole-2-thiol scaffold (NO-IND-OXDs,

Indexed as

IndomethacinMolecular Docking SimulationOxadiazolesCyclooxygenase 2HumansNitric Oxide1,3,4-oxadiazoleCyclooxygenase 2IndomethacinNitric OxideOxadiazolesPTGS2 protein, human1,3,4-oxadiazole-2-thiolcyclooxygenasedocking studyindomethacininflammationnitric oxide

Identifiers

PMID34209248
PMCPMC8267937
OpenAlexW3175904017

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.