Evidence map›Paper›PMID 34209197›Full record

ReviewDiagnostics (Basel, Switzerland)2021

State of the Art in Artificial Intelligence and Radiomics in Hepatocellular Carcinoma.

Anna Castaldo, Davide Raffaele De Lucia, Giuseppe Pontillo, Marco Gatti, Sirio Cocozza, Lorenzo Ugga, Renato Cuocolo

Registry-linked trialAbstract readReview
In one paragraph

Review in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07658586 (A Comprehensive Study of Liver Cancer Diagnosis and Prognosis Prediction Based on Artificial Intelligence and Multimodal Data), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07658586 active not recruitingnot on this mapstarted 2025, after this paper: background citation

A Comprehensive Study of Liver Cancer Diagnosis and Prognosis Prediction Based on Artificial Intelligence and Multimodal Data

TypeobservationalSponsorGuangxi Medical UniversityRan2025 to 2028Enrolled600ConditionsLiver Cancer, Hepatocellular Carcinoma, Intrahepatic Cholangiocarcinoma (Icc)
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anna CastaldoDepartment of Advanced Biomedical Sciences, University of Naples "Federico II", 80131 Naples, Italy.
Davide Raffaele De LuciaDepartment of Advanced Biomedical Sciences, University of Naples "Federico II", 80131 Naples, Italy.
Giuseppe PontilloDepartment of Advanced Biomedical Sciences, University of Naples "Federico II", 80131 Naples, Italy.ORCID 0000-0001-5425-1890
Marco GattiRadiology Unit, Department of Surgical Sciences, University of Turin, 10124 Turin, Italy.ORCID 0000-0001-8168-5280
Sirio CocozzaDepartment of Advanced Biomedical Sciences, University of Naples "Federico II", 80131 Naples, Italy.
Lorenzo UggaDepartment of Advanced Biomedical Sciences, University of Naples "Federico II", 80131 Naples, Italy.ORCID 0000-0001-7811-4612
Renato CuocoloDepartment of Clinical Medicine and Surgery, University of Naples "Federico II", 80131 Naples, Italy.ORCID 0000-0002-1452-1574

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The most common liver malignancy is hepatocellular carcinoma (HCC), which is also associated with high mortality. Often HCC develops in a chronic liver disease setting, and early diagnosis as well as accurate screening of high-risk patients is crucial for appropriate and effective management of these patients. While imaging characteristics of HCC are well-defined in the diagnostic phase, challenging cases still occur, and current prognostic and predictive models are limited in their accuracy. Radiomics and machine learning (ML) offer new tools to address these issues and may lead to scientific breakthroughs with the potential to impact clinical practice and improve patient outcomes. In this review, we will present an overview of these technologies in the setting of HCC imaging across different modalities and a range of applications. These include lesion segmentation, diagnosis, prognostic modeling and prediction of treatment response. Finally, limitations preventing clinical application of radiomics and ML at the present time are discussed, together with necessary future developments to bring the field forward and outside of a purely academic endeavor.

Indexed as

deep learninghepatocellular carcinomaimagingmachine learningradiomics

Identifiers

PMID34209197
PMCPMC8307071

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.