Evidence map›Paper›PMID 34209143›Full record

ArticleJournal of cardiovascular development and disease2021

A History of Heart Failure Is an Independent Risk Factor for Death in Patients Admitted with Coronavirus 19 Disease.

Francesco Castagna, Rachna Kataria, Shivank Madan, Syed Zain Ali, Karim Diab, Christopher Leyton, Angelos Arfaras-Melainis, Paul Kim, Federico M Giorgi, Sasa Vukelic and 4 more

Open access · goldAbstract read
In one paragraph

Article in Journal of cardiovascular development and disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Usefulness of CJournal of clinical medicine · 2022
    Article
  7. Article
  8. Article
  9. Acute and Subclinical Myocardial Injury in COVID-19.Methodist DeBakey cardiovascular journal · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Francesco CastagnaMontefiore Medical Center, Division of Cardiology, Albert Einstein College of Medicine, New York, NY 10467, USA.ORCID 0000-0002-8983-4866
Rachna KatariaMontefiore Medical Center, Division of Cardiology, Albert Einstein College of Medicine, New York, NY 10467, USA.
Shivank MadanMontefiore Medical Center, Division of Cardiology, Albert Einstein College of Medicine, New York, NY 10467, USA.
Syed Zain AliMontefiore Medical Center, Department of Medicine, Albert Einstein College of Medicine, New York, NY 10467, USA.
Karim DiabMontefiore Medical Center, Department of Medicine, Albert Einstein College of Medicine, New York, NY 10467, USA.
Christopher LeytonMontefiore Medical Center, Department of Medicine, Albert Einstein College of Medicine, New York, NY 10467, USA.
Angelos Arfaras-MelainisDepartment of Medicine, NYC Health & Hospitals/Jacobi, Albert Einstein College of Medicine, New York, NY 10461, USA.ORCID 0000-0001-7452-5414
Paul KimMontefiore Medical Center, Department of Medicine, Albert Einstein College of Medicine, New York, NY 10467, USA.
Federico M GiorgiDepartment of Pharmacy and Biotechnology, University of Bologna, 40126 Bologna, Italy.ORCID 0000-0002-7325-9908
Sasa VukelicMontefiore Medical Center, Division of Cardiology, Albert Einstein College of Medicine, New York, NY 10467, USA.
Omar SaeedMontefiore Medical Center, Division of Cardiology, Albert Einstein College of Medicine, New York, NY 10467, USA.
Snehal R PatelMontefiore Medical Center, Division of Cardiology, Albert Einstein College of Medicine, New York, NY 10467, USA.
Daniel B SimsMontefiore Medical Center, Division of Cardiology, Albert Einstein College of Medicine, New York, NY 10467, USA.
Ulrich P JordeMontefiore Medical Center, Division of Cardiology, Albert Einstein College of Medicine, New York, NY 10467, USA.
Albert Einstein College of Medicine · USJacobi Medical Center · USUniversity of Bologna · IT

Funding

Core-010UL1TR001073 · NCATS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI KELLER, MARLA J, SHAMOON, HARRY · 2013 to 2017
$21.3M
Mechanisms of cardiovascular diseaseT32HL144456 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Carlos Jose Rodriguez, Nicholas E Sibinga · 2019 to 2026
$1.9M
Dr. Saeed is supported by grants from the National Institute for Health / National Heart, Lung and Blood Institute (K23HL145140) and the National Center for Advancing Translational Science (NCATS) Clinical and Translational Science Award at Einstein-Monte K23HL145140, UL1TR001073 (see above where applicable)NHLBI NIH HHS T32 HL144456
6 · The paper itself

Abstract

aimsThe association between cardiovascular diseases, such as coronary artery disease and hypertension, and worse outcomes in COVID-19 patients has been previously demonstrated. However, the effect of a prior diagnosis of heart failure (HF) with reduced or preserved left ventricular ejection fraction on COVID-19 outcomes has not yet been established. METHODS AND

resultsWe retrospectively studied all adult patients with COVID-19 admitted to our institution from March 1st to 2nd May 2020. Patients were grouped based on the presence or absence of HF. We used competing events survival models to examine the association between HF and death, need for intubation, or need for dialysis during hospitalization. Of 4043 patients admitted with COVID-19, 335 patients (8.3%) had a prior diagnosis of HF. Patients with HF were older, had lower body mass index, and a significantly higher burden of co-morbidities compared to patients without HF, yet the two groups presented to the hospital with similar clinical severity and similar markers of systemic inflammation. Patients with HF had a higher cumulative in-hospital mortality compared to patients without HF (49.0% vs. 27.2%,

conclusionsThe presence of HF is a risk factor of death, substantially increasing in-hospital mortality in patients admitted with COVID-19.

Indexed as

cardiovascular diseasecorona virus 2019COVID-19epidemiologyheart failurerisk factor

Identifiers

PMID34209143
PMCPMC8307512
OpenAlexW3173473640

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.