Evidence map›Paper›PMID 34209131›Full record

ArticleJournal of clinical medicine2021

Acenocoumarol Pharmacogenetic Dosing Algorithm versus Usual Care in Patients with Venous Thromboembolism: A Randomised Clinical Trial.

Hoi Yan Tong, Alberto M Borobia, Manuel Quintana-Díaz, Sara Fabra, Manuel González-Viñolis, Carmen Fernández-Capitán, María A Rodriguez-Dávila, Alicia Lorenzo, Ana María López-Parra, Nuria Ruiz-Giménez and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Loneliness, Depression, and Genetics in the Elderly: Prognostic Factors of a Worse Health Condition?International journal of environmental research and public health · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 1 country.

Hoi Yan TongClinical Pharmacology Department, La Paz University Hospital, IdiPAZ, 28046 Madrid, Spain.
Alberto M BorobiaClinical Pharmacology Department, La Paz University Hospital, IdiPAZ, 28046 Madrid, Spain.ORCID 0000-0002-8584-3263
Manuel Quintana-DíazGeneral Emergency Department, La Paz University Hospital, IdiPAZ, 28046 Madrid, Spain.ORCID 0000-0003-4852-4148
Sara FabraGeneral Emergency Department, La Paz University Hospital, IdiPAZ, 28046 Madrid, Spain.
Manuel González-ViñolisGeneral Emergency Department, La Paz University Hospital, IdiPAZ, 28046 Madrid, Spain.
Carmen Fernández-CapitánInternal Medicine Department, La Paz University Hospital, IdiPAZ, 28046 Madrid, Spain.
María A Rodriguez-DávilaInternal Medicine Department, La Paz University Hospital, IdiPAZ, 28046 Madrid, Spain.
Alicia LorenzoInternal Medicine Department, La Paz University Hospital, IdiPAZ, 28046 Madrid, Spain.
Ana María López-ParraLaboratory of Population and Forensic Genetics, Department of Legal Medicine, Psyquiatry and Patology, Faculty of Medicine, Complutense University of Madrid, 28040 Madrid, Spain.ORCID 0000-0001-8974-1005
Nuria Ruiz-GiménezDepartment of Internal Medicine, University Hospital La Princesa, 28006 Madrid, Spain.
Francisco Abad-SantosClinical Pharmacology Department, University Hospital La Princesa, Teófilo Hernando Institute, Autonomous University of Madrid (UAM), Health Research Institute La Princesa (IIS-IP), 28006 Madrid, Spain.ORCID 0000-0002-6519-8885
Carmen SuarezDepartment of Internal Medicine, University Hospital La Princesa, 28006 Madrid, Spain.
Olga MadridanoDepartment of Internal Medicine, University Hospital Infanta Sofía, 28702 Madrid, Spain.ORCID 0000-0002-8872-8260
Jorge Francisco Gómez-CerezoDepartment of Internal Medicine, University Hospital Infanta Sofía, 28702 Madrid, Spain.ORCID 0000-0002-3288-5996
Pilar LlamasDepartment of Internal Medicine, University Hospital Jiménez Díaz Foundation, 28040 Madrid, Spain.
Carlos Baeza-RicherLaboratory of Population and Forensic Genetics, Department of Legal Medicine, Psyquiatry and Patology, Faculty of Medicine, Complutense University of Madrid, 28040 Madrid, Spain.
Eduardo Arroyo-PardoLaboratory of Population and Forensic Genetics, Department of Legal Medicine, Psyquiatry and Patology, Faculty of Medicine, Complutense University of Madrid, 28040 Madrid, Spain.ORCID 0000-0003-1851-0589
Antonio J CarcasClinical Pharmacology Department, La Paz University Hospital, IdiPAZ, 28046 Madrid, Spain.
The Pgx-Ace Spanish Investigators Group
Hospital Universitario de La Princesa · ESHospital Universitario La Paz · ESUniversidad Complutense de Madrid · ESHospital Universitario Infanta Sofía · ESUniversidad Autónoma de Madrid · ESHospital Universitario Fundación Jiménez Díaz · ES

Funding

Ministerio de Sanidad, Servicios Sociales e Igualdad TRA-010Research Institute of La Paz University Hospital
6 · The paper itself

Abstract

Patients with venous thromboembolism (VTE) require immediate treatment with anticoagulants such as acenocoumarol. This multicentre randomised clinical trial evaluated the effectiveness of a dosing pharmacogenetic algorithm versus a standard-of-care dose adjustment at the beginning of acenocoumarol treatment. We included 144 patients with VTE. On the day of recruitment, a blood sample was obtained for genotyping (

Indexed as

acenocoumarolclinical trialpharmacogeneticsvenous thromboembolism

Identifiers

PMID34209131
PMCPMC8268204
OpenAlexW3175167072

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.