Evidence map›Paper›PMID 34209129›Full record

ArticleInternational journal of molecular sciences2021

Oral Treatment with RD2RD2 Impedes Development of Motoric Phenotype and Delays Symptom Onset in SOD1

Julia Post, Anja Schaffrath, Ian Gering, Sonja Hartwig, Stefan Lehr, N Jon Shah, Karl-Josef Langen, Dieter Willbold, Janine Kutzsche, Antje Willuweit

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Julia PostInstitute of Biological Information Processing, Structural Biochemistry (IBI-7), Forschungszentrum Jülich, 52425 Jülich, Germany.
Anja SchaffrathInstitute of Biological Information Processing, Structural Biochemistry (IBI-7), Forschungszentrum Jülich, 52425 Jülich, Germany.ORCID 0000-0002-3084-3557
Ian GeringInstitute of Biological Information Processing, Structural Biochemistry (IBI-7), Forschungszentrum Jülich, 52425 Jülich, Germany.ORCID 0000-0003-0965-3908
Sonja HartwigInstitute for Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich-Heine-University Düsseldorf, 40225 Düsseldorf, Germany.ORCID 0000-0002-5225-6804
Stefan LehrInstitute for Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich-Heine-University Düsseldorf, 40225 Düsseldorf, Germany.ORCID 0000-0002-5575-4315
N Jon ShahInstitute of Neuroscience and Medicine, Medical Imaging Physics (INM-4), Forschungszentrum Jülich, 52425 Jülich, Germany.ORCID 0000-0002-8151-6169
Karl-Josef LangenInstitute of Neuroscience and Medicine, Medical Imaging Physics (INM-4), Forschungszentrum Jülich, 52425 Jülich, Germany.ORCID 0000-0003-1101-5075
Dieter WillboldInstitute of Biological Information Processing, Structural Biochemistry (IBI-7), Forschungszentrum Jülich, 52425 Jülich, Germany.ORCID 0000-0002-0065-7366
Janine KutzscheInstitute of Biological Information Processing, Structural Biochemistry (IBI-7), Forschungszentrum Jülich, 52425 Jülich, Germany.ORCID 0000-0003-0271-7390
Antje WilluweitInstitute of Neuroscience and Medicine, Medical Imaging Physics (INM-4), Forschungszentrum Jülich, 52425 Jülich, Germany.ORCID 0000-0002-6725-0755
Forschungszentrum Jülich · DEDeutsches Diabetes-Zentrum e.V. · DE

Funding

Forschungszentrum Jülich Technology Transfer FundImpuls und Vernetzungs-Fonds der Helmholtzgemeinschaft Portfolio Drug ResearchRussian Science Foundation 20-64-46027
6 · The paper itself

Abstract

Neuroinflammation is a pathological hallmark of several neurodegenerative disorders and plays a key role in the pathogenesis of amyotrophic lateral sclerosis (ALS). It has been implicated as driver of disease progression and is observed in ALS patients, as well as in the transgenic SOD1

Indexed as

Administration, OralAmyotrophic Lateral SclerosisAnimalsDisease Models, AnimalMiceMice, TransgenicMotor NeuronsPeptidesSuperoxide DismutasePeptidesSOD1 G93A proteinSuperoxide Dismutaseamyotrophic lateral sclerosisbehaviourd-enantiomeric peptidemotor coordinationneuroinflammationplasma cytokinesSOD1G93A

Identifiers

PMID34209129
PMCPMC8269060
OpenAlexW3175378991

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.