Evidence map›Paper›PMID 34209079›Full record

ArticleInternational journal of molecular sciences2021

Distinct Patterns of HBV Integration and

Jeong-Won Jang, Hye-Seon Kim, Jin-Seoub Kim, Soon-Kyu Lee, Ji-Won Han, Pil-Soo Sung, Si-Hyun Bae, Jong-Young Choi, Seung-Kew Yoon, Dong-Jin Han and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
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  10. The cancer microbiome.Advances in clinical chemistry · 2025
    Review
  11. Review
  12. Article
  13. Review
  14. Relevance of HBx for Hepatitis B Virus-Associated Pathogenesis.International journal of molecular sciences · 2023
    Review
  15. Article
  16. Review
  17. Article
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Jeong-Won JangDivision of Gastroenterology and Hepatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.ORCID 0000-0003-3255-8474
Hye-Seon KimThe Catholic University Liver Research Center, Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Jin-Seoub KimThe Catholic University Liver Research Center, Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Soon-Kyu LeeDivision of Gastroenterology and Hepatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.ORCID 0000-0003-1865-8225
Ji-Won HanDivision of Gastroenterology and Hepatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.ORCID 0000-0003-1456-1450
Pil-Soo SungDivision of Gastroenterology and Hepatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.ORCID 0000-0002-5780-9607
Si-Hyun BaeDivision of Gastroenterology and Hepatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Jong-Young ChoiDivision of Gastroenterology and Hepatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Seung-Kew YoonDivision of Gastroenterology and Hepatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.ORCID 0000-0002-4476-4868
Dong-Jin HanDepartment of Biomedicine & Health Sciences, Graduate School, The Catholic University of Korea, Seoul 06591, Korea.
Tae-Min KimDepartment of Medical Informatics, Cancer Research Institute, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Lewis R RobertsDivision of Gastroenterology and Hepatology, Mayo Clinic College of Medicine and Science, Rochester, MN 55902, USA.ORCID 0000-0001-7885-8574
Catholic University of Korea · KRMayo Clinic · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although hepatitis B virus (HBV) integration into the cellular genome is well known in HCC (hepatocellular carcinoma) patients, its biological role still remains uncertain. This study investigated the patterns of HBV integration and correlated them with

Indexed as

MutationAdultAgedCarcinoma, HepatocellularCase-Control StudiesDNA, ViralFemaleFibronectinsHepatitis BHepatitis B virusHistone-Lysine N-MethyltransferaseHumansLiver NeoplasmsMaleMiddle AgedPromoter Regions, GeneticDNA, ViralFibronectinsFN1 protein, humanhepatitis B virus X proteinHistone-Lysine N-MethyltransferaseMLL4 protein, humanTelomeraseTERT protein, humanTrans-ActivatorsViral Regulatory and Accessory Proteinshepatitis B virusliver cancerpoint mutationtelomerasevirus integration

Identifiers

PMID34209079
PMCPMC8268258
OpenAlexW3174192945

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.