Evidence map›Paper›PMID 34209046›Full record

ReviewGenes2021

The METTL3-m

Alexandra Maldonado López, Brian C Capell

Open access · goldAbstract readReview
In one paragraph

Review in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Review
  6. Mettl3-catalyzed mScience advances · 2023
    Article
  7. Downregulation of mMolecular oncology · 2022
    Article
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Alexandra Maldonado LópezDepartment of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
Brian C CapellDepartment of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
University of Pennsylvania · US

Funding

Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Rebecca A Simmons · 2006 to 2026
$35.3M
Penn Dermatology Research Training ProgramT32AR007465 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI Elizabeth Anne Grice, David Joel Margolis · 1986 to 2026
$9.0M
Epigenetic enhancer control in maintaining homeostasis and preventing carcinogenesis in the epidermisR01AR077615 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI CAPELL, BRIAN · 2020 to 2024
$2.1M
NIAMS NIH HHS R01 AR077615NIAMS NIH HHS T32 AR007465NIEHS NIH HHS P30 ES013508
6 · The paper itself

Abstract

Dynamic modifications on RNA, frequently termed both, "RNA epigenetics" and "epitranscriptomics", offer one of the most exciting emerging areas of gene regulation and biomedicine. Similar to chromatin-based epigenetic mechanisms, writers, readers, and erasers regulate both the presence and interpretation of these modifications, thereby adding further nuance to the control of gene expression. In particular, the most abundant modification on mRNAs, N

Indexed as

Cell DifferentiationGene Expression RegulationTranscriptomeAdenosineEpigenesis, GeneticEpithelial CellsHumansMethyltransferasesNeoplasmsAdenosineMethyltransferasesMETTL3 protein, humanN-methyladenosinecancerdevelopmentdifferentiationepigeneticsepithelialepitranscriptomicsm6AMETTL3RNA

Identifiers

PMID34209046
PMCPMC8303600
OpenAlexW3174755864

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.