ArticleNutrients2021
Oral Ferric Maltol Does Not Adversely Affect the Intestinal Microbiome of Patients or Mice, But Ferrous Sulphate Does.
Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 16 citations in OpenAlex.
- Safety and Efficacy of Oral Ferric Maltol and Ferrous Sulfate for Iron Deficiency Anemia in Infants, Children and Adolescents: A Multicenter Randomized Trial.Paediatric drugs · 2026Trial
- The Gut-Iron-Immune Axis in Severe Anaemia and Bacteraemia.Nutrients · 2026Review
- Ferric Maltol: Pediatric First Approval.Paediatric drugs · 2026Review
- High Dietary Carbonyl Iron Reshapes the Gut Microbiome and Impairs Hepatic Insulin Sensitivity in a Time-Dependent Manner.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Comparative analysis of dietary iron deprivation and supplementation in a murine model of colitis.FASEB bioAdvances · 2025Article
- Oral iron supplementation: new formulations, old questions.Haematologica · 2024Review
- Predicting response to iron supplementation in patients with active inflammatory bowel disease (PRIme): a randomised trial protocol.BMJ open · 2024Article
- Effect of dietary iron supplementation on the equine fecal microbiome.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2023Article
- Fecal Iron Measurement in Studies of the Human Intestinal Microbiome.Current developments in nutrition · 2022Review
- Impact of sucroferric oxyhydroxide on the oral and intestinal microbiome in hemodialysis patients.Scientific reports · 2022Article
- The Usefulness of X-ray Diffraction and Thermal Analysis to Study Dietary Supplements Containing Iron.Molecules (Basel, Switzerland) · 2021Article
- Iron Replacement Therapy with Oral Ferric Maltol: Review of the Evidence and Expert Opinion.Journal of clinical medicine · 2021Review
- Safety, Tolerability, and Pharmacokinetics of Oral Ferric Maltol in Children With Iron Deficiency: Phase 1 Study.JPGN reports · 2021Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
aimsAltering dietary ferrous sulphate (FS) consumption exacerbates a murine model of colitis and alters the intestinal microbiome. We investigated the impact of oral ferric maltol (FM) and FS on mice with dextran sodium sulphate (DSS) induced colitis, and the microbiome of patients with iron deficiency.
methodsMice had acute colitis induced, with 2% DSS for 5 days, followed by water. During this period, groups of mice were fed standard chow (200 ppm iron, SC,
resultsIn mice, after DSS treatment, there was a decrease in many genera in the SC and FSS groups: Lactobacillales increased in mice that received FMS. In humans, FS treatment led to an increase in five genera, but FM was not associated with any measurable change. The severity of DSS-induced colitis was greater with FSS than FMS.
conclusionsThis study demonstrates differential and unique influences of ferric maltol and ferrous sulphate supplements on intestinal microbiota. These differences might contribute to the different side effects associated with these preparations.
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Registered trials
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