Evidence map›Paper›PMID 34208890›Full record

ArticleJournal of clinical medicine2021

Measurement of Electrical Impedance Tomography-Based Regional Ventilation Delay for Individualized Titration of End-Expiratory Pressure.

Thomas Muders, Benjamin Hentze, Stefan Kreyer, Karin Henriette Wodack, Steffen Leonhardt, Göran Hedenstierna, Hermann Wrigge, Christian Putensen

Abstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Thomas MudersDepartment of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, 53127 Bonn, Germany.ORCID 0000-0001-7596-4427
Benjamin HentzeDepartment of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, 53127 Bonn, Germany.ORCID 0000-0003-1071-1861
Stefan KreyerDepartment of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, 53127 Bonn, Germany.
Karin Henriette WodackDepartment of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, 53127 Bonn, Germany.
Steffen LeonhardtChair for Medical Information Technology, RWTH Aachen University, 52074 Aachen, Germany.ORCID 0000-0002-6898-6887
Göran HedenstiernaDepartment of Medical Sciences, Clinical Physiology, Uppsala University, 75185 Uppsala, Sweden.
Hermann WriggeDepartment of Anesthesiology, Intensive Care and Emergency Medicine, Pain Therapy, Bergmannstrost Hospital Halle, 06112 Halle, Germany.
Christian PutensenDepartment of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, 53127 Bonn, Germany.

Funding

Deutsche Forschungsgemeinschaft PU 219/2-1Deutsche Forschungsgemeinschaft WR47-1-1
6 · The paper itself

Abstract

rationaleIndividualized positive end-expiratory pressure (PEEP) titration might be beneficial in preventing tidal recruitment. To detect tidal recruitment by electrical impedance tomography (EIT), the time disparity between the regional ventilation curves (regional ventilation delay inhomogeneity [RVDI]) can be measured during controlled mechanical ventilation when applying a slow inflation of 12 mL/kg of body weight (BW). However, repeated large slow inflations may result in high end-inspiratory pressure (P

methodsDecremental PEEP trials were performed in 15 lung-injured pigs. The PEEP level that minimized tidal recruitment was estimated from EIT-based RVDI measurement during slow inflations of 12, 9, 7.5, or 6 mL/kg BW. We compared RVDI and P

resultsRVDI values from slow inflations of 12 and 9 mL/kg BW showed excellent linear correlation (

conclusionsPEEP titration to minimize tidal recruitment can be individualized according to EIT-based measurement of the time disparity of regional ventilation courses during slow inflations with low inflation volumes

Indexed as

acute respiratory distress syndromeelectrical impedance tomographyfunctional imagingindividualized therapymonitoringpositive end-expiratory pressure

Identifiers

PMID34208890
PMCPMC8267627

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.