Evidence map›Paper›PMID 34208838›Full record

ArticleGenes2021

Analysis of Genetic Variants Associated with Levels of Immune Modulating Proteins for Impact on Alzheimer's Disease Risk Reveal a Potential Role for SIGLEC14.

Benjamin C Shaw, Yuriko Katsumata, James F Simpson, David W Fardo, Steven Estus

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Expression ofGenes · 2023
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Benjamin C ShawDepartment of Physiology, University of Kentucky, Lexington, KY 40506, USA.
Yuriko KatsumataDepartment of Biostatistics, University of Kentucky, Lexington, KY 40506, USA.
James F SimpsonDepartment of Physiology, University of Kentucky, Lexington, KY 40506, USA.
David W FardoSanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40506, USA.ORCID 0000-0002-7207-4696
Steven EstusDepartment of Physiology, University of Kentucky, Lexington, KY 40506, USA.
University of Kentucky · US

Funding

University of Kentucky Alzheimer's Disease Research CenterP30AG072946 · NIA · UNIVERSITY OF KENTUCKY · PI LINDA J VAN ELDIK · 2021 to 2026
$23.5M
University of Kentucky Alzheimer's Disease Core Center - Biomarker CoreP30AG028383 · NIA · UNIVERSITY OF KENTUCKY · PI SCHMITT, FREDERICK · 2006 to 2020
$23.3M
Translating SHIP1 Genetics to Generate a Novel Alzheimers Pharmacologic AgentRF1AG059717 · NIA · UNIVERSITY OF KENTUCKY · PI ESTUS, STEVEN, HUMPHREY, MARY BETH · 2018 to 2019
$3.9M
Novel pathogenetic mechanism for hippocampal sclerosis, a common Alzheimers mimicR01AG057187 · NIA · UNIVERSITY OF KENTUCKY · PI NELSON, PETER T. · 2017 to 2021
$2.2M
Pleiotropy GWAS of Alzheimer's DiseaseR01AG054060 · NIA · UNIVERSITY OF PENNSYLVANIA · PI NAJ, ADAM CHRISTIAN · 2016 to 2020
$2.1M
Genomic Architecture of a Key Alzheimer's Disease Mimic: CARTSR56AG057191 · NIA · UNIVERSITY OF KENTUCKY · PI FARDO, DAVID WILLIAM · 2019 to 2020
$1.1M
Novel misfolded proteins in ADRD: proteomics, genetics, and clinical-pathological correlationsR21AG061551 · NIA · UNIVERSITY OF KENTUCKY · PI NELSON, PETER T. · 2019 to 2020
$421k
How does D2-CD33 reduce Alzheimer's disease risk?R21AG068370 · NIA · UNIVERSITY OF KENTUCKY · PI ESTUS, STEVEN · 2020 to 2020
$421k
NIA NIH HHS P30 AG028383NIA NIH HHS P30 AG072946NIA NIH HHS R01 AG054060NIA NIH HHS R01 AG057187NIA NIH HHS R21 AG061551NIA NIH HHS R21 AG068370NIA NIH HHS R56 AG057191NIA NIH HHS RF1 AG059717
6 · The paper itself

Abstract

Genome-wide association studies (GWAS) have identified immune-related genes as risk factors for Alzheimer's disease (AD), including

Indexed as

DNA Copy Number VariationsGenome-Wide Association StudyPolymorphism, Single NucleotideAged, 80 and overAlzheimer DiseaseBiomarkersCase-Control StudiesFemaleGene DeletionHumansInflammationLectinsMaleQuantitative Trait LociReceptors, Cell SurfaceBiomarkersLectinsReceptors, Cell SurfaceSIGLEC14 protein, humanCNVcopy number variationGWASITAMITIMSIGLEC14SIGLEC5

Identifiers

PMID34208838
PMCPMC8303736
OpenAlexW3175112861

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.