Evidence map›Paper›PMID 34208814›Full record

ArticleMolecules (Basel, Switzerland)2021

Neuroprotective Activities of

Sylvester I Omoruyi, Abobaker S Ibrakaw, Okobi E Ekpo, James S Boatwright, Christopher N Cupido, Ahmed A Hussein

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Alkaloids from In Vitro CulturedPlants (Basel, Switzerland) · 2026
    Article
  2. The Occurrence and Bioactivities ofPlants (Basel, Switzerland) · 2025
    Review
  3. Article
  4. Article
  5. Review
  6. Neuroprotective Effects ofPharmaceuticals (Basel, Switzerland) · 2024
    Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Alkaloids in Future Drug Discovery.Molecules (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Sylvester I OmoruyiDepartment of Chemistry, Cape Peninsula University of Technology, Symphony Road, Bellville 7535, South Africa.
Abobaker S IbrakawDepartment of Biodiversity and Conservation Biology, University of the Western Cape, Cape Town, Robert Sobukwe Road, Bellville 7535, South Africa.
Okobi E EkpoDepartment of Anatomy and Cellular Biology, College of Medicine and Health Sciences, Khalifa University, Abu Dhabi P.O. Box 127788, United Arab Emirates.
James S BoatwrightDepartment of Biodiversity and Conservation Biology, University of the Western Cape, Cape Town, Robert Sobukwe Road, Bellville 7535, South Africa.
Christopher N CupidoDepartment of Botany, University of Fort Hare, Private Bag X1314, Alice 5700, South Africa.
Ahmed A HusseinDepartment of Chemistry, Cape Peninsula University of Technology, Symphony Road, Bellville 7535, South Africa.ORCID 0000-0002-3877-9959
Cape Peninsula University of Technology · ZAUniversity of the Western Cape · ZAKhalifa University of Science and Technology · AEUniversity of Fort Hare · ZA

Funding

National Research Foundation, South Africa 106055-2016
6 · The paper itself

Abstract

Parkinson's disease (PD) is one of the most common neurodegenerative diseases and affects approximately 6.3 million people worldwide. To date, the treatment of PD remains a challenge, as available treatment options are known to be associated with serious side effects; hence, the search for new treatment strategies is critical. Extracts from the Amaryllidaceae plant family as well as their alkaloids have been reported to have neuroprotective potentials. This study, therefore, investigated the biological activities of

Indexed as

AmaryllidaceaeAmaryllidaceae AlkaloidsCell Line, TumorHumansMPTP PoisoningNeuroprotectionNeuroprotective AgentsOxidative StressSignal TransductionAmaryllidaceae AlkaloidsNeuroprotective Agents1-methyl-4-phenylpyridinium (MPP+)alkaloidsAmaryllidaceaeCrossyne flavaneuroprotectionParkinson’s disease

Identifiers

PMID34208814
PMCPMC8272225
OpenAlexW3174690034

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.