Evidence map›Paper›PMID 34208772›Full record

ArticleInternational journal of molecular sciences2021

Isookanin Inhibits PGE

Yingji Xin, Kyungbaeg Roh, Eunae Cho, Deokhoon Park, Wankyunn Whang, Eunsun Jung

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Down-regulation of β-lactam antibiotics resistance and biofilm formation byFrontiers in cellular and infection microbiology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yingji XinBiospectrum Life Science Institute, Yongin 16827, Korea.ORCID 0000-0002-6106-3713
Kyungbaeg RohBiospectrum Life Science Institute, Yongin 16827, Korea.ORCID 0000-0003-4542-5582
Eunae ChoBiospectrum Life Science Institute, Yongin 16827, Korea.
Deokhoon ParkBiospectrum Life Science Institute, Yongin 16827, Korea.
Wankyunn WhangDepartment of Global Innovative Drug, Graduate School, College of Pharmacy, Chung-Ang University, Heukseok-dong, Dongjak-gu, Seoul 156756, Korea.ORCID 0000-0003-4128-3177
Eunsun JungBiospectrum Life Science Institute, Yongin 16827, Korea.ORCID 0000-0002-5594-4645
Chung-Ang University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammation is increasingly recognized as a critical mediator of angiogenesis, and unregulated angiogenic responses often involve human diseases. The importance of regulating angiogenesis in inflammatory diseases has been demonstrated through some successful cases of anti-angiogenesis therapies in related diseases, including arthritis, but it has been reported that some synthetic types of antiangiogenic drugs have potential side effects. In recent years, the importance of finding alternative strategies for regulating angiogenesis has begun to attract the attention of researchers. Therefore, identification of natural ingredients used to prevent or treat angiogenesis-related diseases will play a greater role. Isookanin is a phenolic flavonoid presented in

Indexed as

Cell Cycle CheckpointsCell Cycle ProteinsCell MovementCell ProliferationChalconesCyclic AMP Response Element-Binding ProteinDinoprostoneEndothelial CellsHumansMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Models, BiologicalNeovascularization, PhysiologicPhosphorylationCell Cycle ProteinsChalconesCREB1 protein, humanCyclic AMP Response Element-Binding ProteinDinoprostoneisookaninMAPK1 protein, humanMAPK3 protein, humanMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3anti-angiogenesiscell cycle arrestERK1/2 and CREB signaling pathwayHMEC-1 cellisookaninprostaglandin E2 (PGE2)

Identifiers

PMID34208772
PMCPMC8234715
OpenAlexW3170191460

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.