Evidence map›Paper›PMID 34208698›Full record

ArticleAntibiotics (Basel, Switzerland)2021

Evaluation of Benzguinols as Next-Generation Antibiotics for the Treatment of Multidrug-Resistant Bacterial Infections.

Hang Thi Nguyen, Mahmud T Morshed, Daniel Vuong, Andrew Crombie, Ernest Lacey, Sanjay Garg, Hongfei Pi, Lucy Woolford, Henrietta Venter, Stephen W Page and 3 more

Open access · goldAbstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Microbiology spectrum · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Hang Thi NguyenAustralian Centre for Antimicrobial Resistance Ecology, School of Animal and Veterinary Sciences, Roseworthy Campus, The University of Adelaide, Roseworthy, SA 5371, Australia.ORCID 0000-0002-6313-9371
Mahmud T MorshedDepartment of Molecular Sciences, Macquarie University, Sydney, NSW 2109, Australia.ORCID 0000-0003-1839-7520
Daniel VuongMicrobial Screening Technologies Pty. Ltd., Smithfield, NSW 2164, Australia.ORCID 0000-0002-2451-3148
Andrew CrombieMicrobial Screening Technologies Pty. Ltd., Smithfield, NSW 2164, Australia.
Ernest LaceyDepartment of Molecular Sciences, Macquarie University, Sydney, NSW 2109, Australia.
Sanjay GargClinical and Health Sciences, University of South Australia, Adelaide, SA 5000, Australia.ORCID 0000-0001-7253-2629
Hongfei PiAustralian Centre for Antimicrobial Resistance Ecology, School of Animal and Veterinary Sciences, Roseworthy Campus, The University of Adelaide, Roseworthy, SA 5371, Australia.ORCID 0000-0002-5758-6044
Lucy WoolfordSchool of Animal and Veterinary Sciences, Roseworthy Campus, The University of Adelaide, Roseworthy, SA 5371, Australia.
Henrietta VenterHealth and Biomedical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide, SA 5000, Australia.ORCID 0000-0001-5569-7755
Stephen W PageAdvanced Veterinary Therapeutics, Newtown, NSW 2042, Australia.
Andrew M PiggottDepartment of Molecular Sciences, Macquarie University, Sydney, NSW 2109, Australia.ORCID 0000-0002-5308-5314
Darren J TrottAustralian Centre for Antimicrobial Resistance Ecology, School of Animal and Veterinary Sciences, Roseworthy Campus, The University of Adelaide, Roseworthy, SA 5371, Australia.
Abiodun D OgunniyiAustralian Centre for Antimicrobial Resistance Ecology, School of Animal and Veterinary Sciences, Roseworthy Campus, The University of Adelaide, Roseworthy, SA 5371, Australia.ORCID 0000-0001-9308-5629
The University of Adelaide · AUMacquarie University · AUUniversity of South Australia · AUVietnam National University of Agriculture · VN

Funding

Cooperative Research Centres, Australian Government Department of Industry CRCPFIVE000119
6 · The paper itself

Abstract

Our recent focus on the "lost antibiotic" unguinol and related nidulin-family fungal natural products identified two semisynthetic derivatives, benzguinols A and B, with unexpected in vitro activity against

Indexed as

antimicrobial resistancebenzguinolsbioluminescent mouse modelcolistincytotoxicityGram-negativeminimum inhibitory concentrationnidulinsStaphylococcus aureusStaphylococcus pseudintermedius

Identifiers

PMID34208698
PMCPMC8233939
OpenAlexW3169649467

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.