Evidence map›Paper›PMID 34208623›Full record

ArticleMolecules (Basel, Switzerland)2021

Concise Synthesis of Both Enantiomers of Pilocarpine.

Theresa Schmidt, Niels Heise, Kurt Merzweiler, Hans-Peter Deigner, Ahmed Al-Harrasi, René Csuk

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Phytochemicals fromMolecules (Basel, Switzerland) · 2023
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Theresa SchmidtDepartment of Organic Chemistry, Martin-Luther University Halle-Wittenberg, Kurt-Mothes Str. 2, D-06120 Halle (Saale), Germany.
Niels HeiseDepartment of Organic Chemistry, Martin-Luther University Halle-Wittenberg, Kurt-Mothes Str. 2, D-06120 Halle (Saale), Germany.ORCID 0000-0002-6540-6357
Kurt MerzweilerDepartment of Inorganic Chemistry, Martin-Luther University Halle-Wittenberg, Kurt-Mothes Str. 2, D-06120 Halle (Saale), Germany.
Hans-Peter DeignerMedical and Life Science Faculty, Institute of Precision Medicine, Furtwangen University, Jakob-Kienzle, Str. 17, D-78054 Villingen-Schwenningen, Germany.
Ahmed Al-HarrasiChair of Oman's Medicinal Plants and Marine Natural Products, University of Nizwa, P.O. Box 33, PC 616 Nizwa, Oman.ORCID 0000-0002-0815-5942
René CsukDepartment of Organic Chemistry, Martin-Luther University Halle-Wittenberg, Kurt-Mothes Str. 2, D-06120 Halle (Saale), Germany.ORCID 0000-0001-7911-290X
Martin Luther University Halle-Wittenberg · DEFurtwangen University · DEUniversity of Nizwa · OM

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Furan-2-carboxylic acid was used as a starting material for the synthesis of dehydro-homopilopic acid. Esterification, hydrogenation and enzymatic hydrolysis followed by the reduction of Weinreb amides and a single-step attachment of a 1-methyl-imidazole residue allowed for the concise synthesis of both enantiomers of pilocarpine.

Indexed as

4-ButyrolactoneAmidesCarboxylic AcidsEsterificationFuransHydrogenationHydrolysisPilocarpineStereoisomerism2-furoic acid4-ButyrolactoneAmidesCarboxylic AcidsFuranshomopilopic acidPilocarpinealkaloidsenzymatic resolutionpilocarpine

Identifiers

PMID34208623
PMCPMC8235342
OpenAlexW3176002015

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.