Evidence map›Paper›PMID 34208595›Full record

ReviewCancers2021

Systematic Review on the Association of Radiomics with Tumor Biological Endpoints.

Agustina La Greca Saint-Esteven, Diem Vuong, Fabienne Tschanz, Janita E van Timmeren, Riccardo Dal Bello, Verena Waller, Martin Pruschy, Matthias Guckenberger, Stephanie Tanadini-Lang

Abstract readReview
In one paragraph

Review in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Artificial intelligence in the diagnosis and management of gynecologic cancer.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Agustina La Greca Saint-EstevenDepartment of Radiation Oncology, University Hospital Zurich and University of Zurich, 8091 Zurich, Switzerland.ORCID 0000-0003-4504-611X
Diem VuongDepartment of Radiation Oncology, University Hospital Zurich and University of Zurich, 8091 Zurich, Switzerland.ORCID 0000-0001-7153-4219
Fabienne TschanzLaboratory of Applied Radiobiology, Department of Radiation Oncology, University of Zurich, 8091 Zurich, Switzerland.
Janita E van TimmerenDepartment of Radiation Oncology, University Hospital Zurich and University of Zurich, 8091 Zurich, Switzerland.
Riccardo Dal BelloDepartment of Radiation Oncology, University Hospital Zurich and University of Zurich, 8091 Zurich, Switzerland.ORCID 0000-0002-8755-377X
Verena WallerLaboratory of Applied Radiobiology, Department of Radiation Oncology, University of Zurich, 8091 Zurich, Switzerland.ORCID 0000-0001-5856-1968
Martin PruschyLaboratory of Applied Radiobiology, Department of Radiation Oncology, University of Zurich, 8091 Zurich, Switzerland.ORCID 0000-0002-3124-9015
Matthias GuckenbergerDepartment of Radiation Oncology, University Hospital Zurich and University of Zurich, 8091 Zurich, Switzerland.ORCID 0000-0002-7146-9071
Stephanie Tanadini-LangDepartment of Radiation Oncology, University Hospital Zurich and University of Zurich, 8091 Zurich, Switzerland.ORCID 0000-0002-4387-1522

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 310030_173303
6 · The paper itself

Abstract

Radiomics supposes an alternative non-invasive tumor characterization tool, which has experienced increased interest with the advent of more powerful computers and more sophisticated machine learning algorithms. Nonetheless, the incorporation of radiomics in cancer clinical-decision support systems still necessitates a thorough analysis of its relationship with tumor biology. Herein, we present a systematic review focusing on the clinical evidence of radiomics as a surrogate method for tumor molecular profile characterization. An extensive literature review was conducted in PubMed, including papers on radiomics and a selected set of clinically relevant and commonly used tumor molecular markers. We summarized our findings based on different cancer entities, additionally evaluating the effect of different modalities for the prediction of biomarkers at each tumor site. Results suggest the existence of an association between the studied biomarkers and radiomics from different modalities and different tumor sites, even though a larger number of multi-center studies are required to further validate the reported outcomes.

Indexed as

cancerimaging biomarkerradiomicstumor biologytumor molecular marker

Identifiers

PMID34208595
PMCPMC8234501

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.