ReviewMicroorganisms2021
Cariogenic Biofilm: Pathology-Related Phenotypes and Targeted Therapy.
Review in Microorganisms, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Key virulence genes associated withFrontiers in oral health · 2025Pooled it
- Preliminary species-dependent growth responses of selected oral bacteria to e-cigarette Liquids and aerosol extracts: a single-species in vitro study.BMC oral health · 2026Article
- Research progress of AI assisted nano-SERS technology in rapid identification of multi species oral pathogenic biofilms.Mikrochimica acta · 2026Review
- Heavy Metal-Driven Oral Dysbiosis: Salivary Toxicometallomics at the Host-Microbiome Interface Across Pathologies.Life (Basel, Switzerland) · 2026Review
- Supragingival dental biofilm microbiomes of tobacco heating system smokers, cigarette smokers and non-smokers.Clinical oral investigations · 2026Article
- An Exploration of Nanobiotechnology Bridging Patho-Therapeutics with Regenerative and Clinical Perspectives in Periodontitis.Journal of functional biomaterials · 2026Review
- Buprenorphine enhancesJournal of oral microbiology · 2026Article
- Evaluating microbial regulation as a preventive strategy for radiation-related caries: A review.Head & face medicine · 2025Review
- Photocatalytic TiORSC advances · 2025Article
- The Clinical and Antibacterial Effects of a Herbal Toothpaste Containing White MustardDentistry journal · 2025Article
- Biofilm Resilience: Molecular Mechanisms Driving Antibiotic Resistance in Clinical Contexts.Biology · 2025Review
- Imbalance of oral microbiome homeostasis: the relationship between microbiota and the occurrence of dental caries.BMC microbiology · 2025Article
- Resin-based dental pulp capping restoration enclosing silica and portlandite nanoparticles from natural resources.Scientific reports · 2024Article
- Recent advances in the pathogenesis and prevention strategies of dental calculus.NPJ biofilms and microbiomes · 2024Review
- Inhibitory effect ofFrontiers in microbiology · 2024Article
- Effects of caffeic acid phenethyl ester against multi-species cariogenic biofilms.Folia microbiologica · 2023Article
- Antimicrobial Effects of Edible Mixed Herbal Extracts on Oral Microorganisms: An In Vitro Study.Medicina (Kaunas, Lithuania) · 2023Article
- The Anti-Caries Effects of a Novel Peptide on Dentine Caries: An In Vitro Study.International journal of molecular sciences · 2023Article
- Novel Lactotransferrin-Derived Antimicrobial Peptide LF-1 Inhibits the Cariogenic Virulence Factors ofAntibiotics (Basel, Switzerland) · 2023Article
- Oral biofilms - pivotal role in understanding microbes and their relevance to the human host.Germs · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The initiation and development of cariogenic (that is, caries-related) biofilms are the result of the disruption of homeostasis in the oral microenvironment. There is a daily accumulation of dental biofilm on the surface of teeth and its matrix of extracellular polymers supports the host in its defense against invading microbes, thus helping to achieve oral microbial homeostasis. However, the homeostasis can be broken down under certain circumstances such as during long-term exposure to a low pH environment which results in the dominance of acidogenic and acid-tolerating species in the dental biofilm and, thus, triggers the shift of harmless biofilm to an acidic one. This work aims to explore microbial diversity and the quorum sensing of dental biofilm and their important contributions to oral health and disease. The complex and multispecies ecosystems of the cariogenic biofilm pose significant challenges for the modulation of the oral microenvironment. Promising treatment strategies are those that target cariogenic niches with high specificity without disrupting the balance of the surrounding oral microbiota. Here, we summarized the recent advances in modulating cariogenic biofilm and/or controlling its pathogenic traits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.