Evidence map›Paper›PMID 34208563›Full record

ArticleInternational journal of molecular sciences2021

Synergistic Effect of PVDF-Coated PCL-TCP Scaffolds and Pulsed Electromagnetic Field on Osteogenesis.

Yibing Dong, Luvita Suryani, Xinran Zhou, Padmalosini Muthukumaran, Moumita Rakshit, Fengrui Yang, Feng Wen, Ammar Mansoor Hassanbhai, Kaushik Parida, Daniel T Simon and 4 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
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  3. Review
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  5. Article
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  7. Article
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  9. Article
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  11. Smart Orthopedic Biomaterials and Implants.Current opinion in biomedical engineering · 2023
    Article
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  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 4 countries.

Yibing DongSchool of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore.
Luvita SuryaniSchool of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore 637459, Singapore.
Xinran ZhouSchool of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore.
Padmalosini MuthukumaranSchool of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore 637459, Singapore.
Moumita RakshitSchool of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore.
Fengrui YangSchool of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore 637459, Singapore.
Feng WenSchool of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore 637459, Singapore.
Ammar Mansoor HassanbhaiSchool of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore 637459, Singapore.
Kaushik ParidaSchool of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore.
Daniel T SimonLaboratory of Organic Electronics, Department of Science and Technology, Linköping University, 601 74 Norrköping, Sweden.
Donata IandoloLaboratory of Organic Electronics, Department of Science and Technology, Linköping University, 601 74 Norrköping, Sweden.ORCID 0000-0002-8090-8427
Pooi See LeeSchool of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore.ORCID 0000-0003-1383-1623
Kee Woei NgSchool of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore.ORCID 0000-0002-7276-3563
Swee Hin TeohSchool of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore 637459, Singapore.
Nanyang Technological University · SGLinköping University · SEHarvard University · US

Funding

Agency for Science, Technology and Research AMBM, A18A8b0059Ministry of Education - Singapore MOE2016-T2-2-108Nanyang Technological University CHAIR PROFESSORSHIPS
6 · The paper itself

Abstract

Bone exhibits piezoelectric properties. Thus, electrical stimulations such as pulsed electromagnetic fields (PEMFs) and stimuli-responsive piezoelectric properties of scaffolds have been investigated separately to evaluate their efficacy in supporting osteogenesis. However, current understanding of cells responding under the combined influence of PEMF and piezoelectric properties in scaffolds is still lacking. Therefore, in this study, we fabricated piezoelectric scaffolds by functionalization of polycaprolactone-tricalcium phosphate (PCL-TCP) films with a polyvinylidene fluoride (PVDF) coating that is self-polarized by a modified breath-figure technique. The osteoinductive properties of these PVDF-coated PCL-TCP films on MC3T3-E1 cells were studied under the stimulation of PEMF. Piezoelectric and ferroelectric characterization demonstrated that scaffolds with piezoelectric coefficient

Indexed as

Calcium PhosphatesCoated Materials, BiocompatibleElectromagnetic FieldsOsteogenesisPolyestersPolyvinylsTissue ScaffoldsBone RegenerationCell DifferentiationCell ProliferationCells, CulturedFluorocarbon PolymersGene ExpressionSolventsTissue EngineeringX-Ray DiffractionCalcium PhosphatesCoated Materials, BiocompatibleFluorocarbon PolymerspolycaprolactonePolyesterspolyvinylidene fluoridePolyvinylsSolventstricalcium phosphatebone tissue engineeringelectrical stimulationelectroactive biomaterialpiezoelectric scaffoldpulsed electromagnetic fieldstimuli-responsive materials

Identifiers

PMID34208563
PMCPMC8234164
OpenAlexW3168024599

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.