Evidence map›Paper›PMID 34208557›Full record

ArticleInternational journal of molecular sciences2021

In Vitro Inhibition of Renal OCT2 and MATE1 Secretion by Antiemetic Drugs.

Blessy George, Xia Wen, Edgar A Jaimes, Melanie S Joy, Lauren M Aleksunes

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Trial
  2. Beyond SGLT2: proximal tubule transporters as potential drug targets for chronic kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Review
  3. Understanding Cisplatin Pharmacokinetics and Toxicodynamics to Predict and Prevent Kidney Injury.The Journal of pharmacology and experimental therapeutics · 2024
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Pharmaceutics · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Blessy GeorgeDepartment of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, 170 Frelinghuysen Road, Piscataway, NJ 08854, USA.
Xia WenDepartment of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, 170 Frelinghuysen Road, Piscataway, NJ 08854, USA.
Edgar A JaimesRenal Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Melanie S JoyDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO 80045, USA.
Lauren M AleksunesDepartment of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, 170 Frelinghuysen Road, Piscataway, NJ 08854, USA.ORCID 0000-0002-0032-1037
Rutgers, The State University of New Jersey · USMemorial Sloan Kettering Cancer Center · USUniversity of Colorado Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
TRANSCRIPTIONAL PROFILINGP30CA072720 · NCI · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI Tracie Saunders · 1997 to 2026
$94.5M
Translational Research Support CoreP30ES005022 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI BRIAN T BUCKLEY · 1988 to 2026
$47.4M
TRAINING IN EVIRONMENTAL TOXICOLOGYT32ES007148 · NIEHS · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI Lauren M Aleksunes · 1987 to 2026
$11.4M
Drug Disposition and NephrotoxicityR01GM123330 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI ALEKSUNES, LAUREN M, JOY, MELANIE S · 2018 to 2021
$2.1M
Pharmacokinetic and Pharmacogenomic Determinants of Cisplatin Kidney InjuryR21DK093903 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI ALEKSUNES, LAUREN M, JOY, MELANIE S · 2012 to 2013
$423k
NCI NIH HHS CA008748NCI NIH HHS CA046934NCI NIH HHS CA072720NCI NIH HHS P30 CA008748NIDDK NIH HHS DK093903NIEHS NIH HHS ES005022NIEHS NIH HHS ES007148NIEHS NIH HHS P30 ES005022NIEHS NIH HHS T32 ES007148NIGMS NIH HHS GM123330
6 · The paper itself

Abstract

The organic cation transporter 2 (OCT2) and multidrug and toxin extrusion protein 1 (MATE1) mediate the renal secretion of drugs. Recent studies suggest that ondansetron, a 5-HT

Indexed as

AnimalsAntiemeticsBiological TransportCell LineCells, CulturedDogsGene ExpressionHEK293 CellsHumansKidneyMadin Darby Canine Kidney CellsMolecular StructureOrganic Cation Transporter 2Organic Cation Transport ProteinsSerotonin 5-HT3 Receptor AntagonistsAntiemeticsOrganic Cation Transporter 2Organic Cation Transport ProteinsSerotonin 5-HT3 Receptor AntagonistsSLC47A1 protein, human5-HT3 antagonistcationickidneyMATE1OCT2secretiontransport

Identifiers

PMID34208557
PMCPMC8234231
OpenAlexW3172001513

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.