Evidence map›Paper›PMID 34208488›Full record

ArticleNutrients2021

Ketogenic Dietary Therapies in Patients with Autism Spectrum Disorder: Facts or Fads? A Scoping Review and a Proposal for a Shared Protocol.

Costanza Varesio, Serena Grumi, Martina Paola Zanaboni, Martina Maria Mensi, Matteo Chiappedi, Ludovica Pasca, Cinzia Ferraris, Anna Tagliabue, Renato Borgatti, Valentina De Giorgis

Abstract readScoping Review
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
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  10. Article
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  14. Diet in treatment of autism spectrum disorders.Frontiers in neuroscience · 2022
    Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Costanza VaresioDepartment of Child Neurology and Psychiatry, IRCCS Mondino Foundation, 27100 Pavia, Italy.ORCID 0000-0001-5645-021X
Serena GrumiDepartment of Child Neurology and Psychiatry, IRCCS Mondino Foundation, 27100 Pavia, Italy.ORCID 0000-0003-4353-3803
Martina Paola ZanaboniDepartment of Child Neurology and Psychiatry, IRCCS Mondino Foundation, 27100 Pavia, Italy.
Martina Maria MensiDepartment of Child Neurology and Psychiatry, IRCCS Mondino Foundation, 27100 Pavia, Italy.ORCID 0000-0002-9583-0554
Matteo ChiappediDepartment of Child Neurology and Psychiatry, IRCCS Mondino Foundation, 27100 Pavia, Italy.ORCID 0000-0002-2682-5006
Ludovica PascaDepartment of Child Neurology and Psychiatry, IRCCS Mondino Foundation, 27100 Pavia, Italy.
Cinzia FerrarisHuman Nutrition and Eating Disorder Research Center, Department of Public Health, Experimental and Forensic Medicine University of Pavia, 27100 Pavia, Italy.ORCID 0000-0002-4148-2136
Anna TagliabueHuman Nutrition and Eating Disorder Research Center, Department of Public Health, Experimental and Forensic Medicine University of Pavia, 27100 Pavia, Italy.
Renato BorgattiDepartment of Child Neurology and Psychiatry, IRCCS Mondino Foundation, 27100 Pavia, Italy.
Valentina De GiorgisDepartment of Child Neurology and Psychiatry, IRCCS Mondino Foundation, 27100 Pavia, Italy.ORCID 0000-0002-5828-7070

Funding

Ministero della Salute RC 2020-2021
6 · The paper itself

Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental disorder with increasing incidence. An expanding body of literature is examining connections between ASD and dietary interventions. Existing reports suggest a beneficial effect of ketogenic dietary therapies (KDTs) in improving behavioral symptoms in ASD. In this context, the purpose of this scoping review was to identify and map available evidence in the literature about the feasibility and potential efficacy of KDTs in pediatric patients with ASD and to inform clinical practice in the field. Moreover, based on the resulting data from the literature review, we aimed to provide a shared protocol to develop a personalized KDT intervention in patients with ASD. A comprehensive and structured web-based literature search was performed using PubMed and Scopus and it yielded 203 records. Seven papers were finally selected and included in the review. Data were abstracted by independent coders. High variability was identified in study designs and dietary aspects emerged among selected studies. Results supported the effectiveness of KDTs in promoting behavioral improvements. Clinical recommendations on which patients may benefit most from KDTs implementation and difficulties in dietary adherence were discussed.

Indexed as

Autism Spectrum DisorderDiet, KetogenicHumansTreatment Outcomeautism spectrum disorderdietary protocolketogenic dietscoping review

Identifiers

PMID34208488
PMCPMC8234312

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.