ArticleMicroorganisms2021
Microbiome of Odontogenic Abscesses.
Article in Microorganisms, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Antibiotic resistance in odontogenic infections: A systematic review of current evidence and implications for guideline-based therapy.Clinical oral investigations · 2026Pooled it
- Bacterial Profile and Antibiotic Resistance in Oral and Maxillofacial Infections.Journal of clinical medicine · 2026Article
- Cultured microbial community complexity is associated with antimicrobial resistance and Enterobacterales enrichment in adult odontogenic infections.Oral and maxillofacial surgery · 2026Article
- Paired oral clinical specimens reveal the underlying ecology supporting the emergence of inflammophilic microbiome communities.bioRxiv : the preprint server for biology · 2026Article
- Clinical impact of antibiotic resistance in odontogenic infections: a 12-year analysis of 740 cases.Clinical oral investigations · 2025Article
- Microbiological and Clinical Predictors of Surgical Intervention in Odontogenic Sinusitis.Journal of clinical medicine · 2025Article
- Results of bacterial cultivation are infrequently utilized in the treatment of patients hospitalized with severe odontogenic infections - a retrospective cohort study.Journal of oral microbiology · 2025Article
- High prevalence of antibiotic resistance ofJournal of oral microbiology · 2025Article
- Microbial spectrum and resistance of odontogenic abscesses - microbiological analysis using next generation sequencing.Clinical oral investigations · 2024Article
- Article
- Influences of ultrasound osteotome on wound infection and wound complications following removal of mandibular wisdom teeth.International wound journal · 2024Article
- An inflammatory paradox: strategies inflammophilic oral pathobionts employ to exploit innate immunity via neutrophil manipulation.Frontiers in oral health · 2024Article
- Forecasting the development of antimicrobial resistance ofFrontiers in oral health · 2024Article
- Pleural Empyema Caused by Streptococcus intermedius and Fusobacterium nucleatum: A Distinct Entity of Pleural Infections.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Root Canal Infection and Its Impact on the Oral Cavity Microenvironment in the Context of Immune System Disorders in Selected Diseases: A Narrative Review.Journal of clinical medicine · 2023Review
- Evolution of the treatment of severe odontogenic infections over 50 years: A comprehensive review.Journal of Taibah University Medical Sciences · 2023Review
- Clinical Microbial Identification of Severe Oral Infections by MALDI-TOF Mass Spectrometry in Stockholm County: an 11-Year (2010 to 2020) Epidemiological Investigation.Microbiology spectrum · 2022Article
- Genetic Homology between Bacteria Isolated from Pulmonary Abscesses or Pyothorax and Bacteria from the Oral Cavity.Microbiology spectrum · 2022Article
- Odontogenic Cervicofacial Necrotizing Fasciitis: Microbiological Characterization and Management of Four Clinical Cases.Pathogens (Basel, Switzerland) · 2022Article
- Rare brain and pulmonary abscesses caused by oral pathogens started with acute gastroenteritis diagnosed by metagenome next-generation sequencing: A case report and literature review.Frontiers in cellular and infection microbiology · 2022Review
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
Severe odontogenic abscesses are regularly caused by bacteria of the physiological oral microbiome. However, the culture of these bacteria is often prone to errors and sometimes does not result in any bacterial growth. Furthermore, various authors found completely different bacterial spectra in odontogenic abscesses. Experimental 16S rRNA gene next-generation sequencing analysis was used to identify the microbiome of the saliva and the pus in patients with a severe odontogenic infection. The microbiome of the saliva and the pus was determined for 50 patients with a severe odontogenic abscess. Perimandibular and submandibular abscesses were the most commonly observed diseases at 15 (30%) patients each. Polymicrobial infections were observed in 48 (96%) cases, while the picture of a mono-infection only occurred twice (4%). On average, 31.44 (±12.09) bacterial genera were detected in the pus and 41.32 (±9.00) in the saliva. In most cases, a predominantly anaerobic bacterial spectrum was found in the pus, while saliva showed a similar oral microbiome to healthy individuals. In the majority of cases, odontogenic infections are polymicrobial. Our results indicate that these are mainly caused by anaerobic bacterial strains and that aerobic and facultative anaerobe bacteria seem to play a more minor role than previously described by other authors. The 16S rRNA gene analysis detects significantly more bacteria than conventional methods and molecular methods should therefore become a part of routine diagnostics in medical microbiology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.