Evidence map›Paper›PMID 34208421›Full record

ArticleMolecules (Basel, Switzerland)2021

Novel Substrates for Kinases Involved in the Biosynthesis of Inositol Pyrophosphates and Their Enhancement of ATPase Activity of a Kinase.

Raja Mohanrao, Ruth Manorama, Shubhra Ganguli, Mithun C Madhusudhanan, Rashna Bhandari, Kana M Sureshan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Raja MohanraoSchool of Chemistry, Indian Institute of Science Education and Research Thiruvananthapuram, Kerala 695551, India.ORCID 0000-0001-6234-9134
Ruth ManoramaLaboratory of Cell Signalling, Centre for DNA Fingerprinting and Diagnostics, Hyderabad 500039, India.
Shubhra GanguliLaboratory of Cell Signalling, Centre for DNA Fingerprinting and Diagnostics, Hyderabad 500039, India.
Mithun C MadhusudhananSchool of Chemistry, Indian Institute of Science Education and Research Thiruvananthapuram, Kerala 695551, India.ORCID 0000-0002-3122-0802
Rashna BhandariLaboratory of Cell Signalling, Centre for DNA Fingerprinting and Diagnostics, Hyderabad 500039, India.ORCID 0000-0003-3101-0204
Kana M SureshanSchool of Chemistry, Indian Institute of Science Education and Research Thiruvananthapuram, Kerala 695551, India.ORCID 0000-0002-4005-3655
Indian Institute of Science Education and Research Thiruvananthapuram · INCentre for DNA Fingerprinting and Diagnostics · INManipal Academy of Higher Education · IN

Funding

Department of Biotechnology, Ministry of Science and Technology, India BT/PR29960/BRB/10/1762/2019Department of Science and Technology, Ministry of Science and Technology, India DST/SJF/CSA-02/2012-13Science and Engineering Research Board CRG/20l9/002597
6 · The paper itself

Abstract

IP6K and PPIP5K are two kinases involved in the synthesis of inositol pyrophosphates. Synthetic analogs or mimics are necessary to understand the substrate specificity of these enzymes and to find molecules that can alter inositol pyrophosphate synthesis. In this context, we synthesized four

Indexed as

Adenosine TriphosphatasesAnimalsEnzyme AssaysInositolInositol PhosphatesMiceMolecular Docking SimulationPhosphorylationPhosphotransferases (Phosphate Group Acceptor)Signal TransductionSubstrate SpecificityAdenosine TriphosphatasesIhpk1 protein, mouseInositolinositol hexakisphosphate kinaseInositol PhosphatesPhosphotransferases (Phosphate Group Acceptor)scyllitolATPaseinositol pyrophosphateIP6K1kinaseVIP1 KD

Identifiers

PMID34208421
PMCPMC8231259
OpenAlexW3169157417

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.