ArticleSensors (Basel, Switzerland)2021
Texture Analysis of Dried Droplets for the Quality Control of Medicines.
Article in Sensors (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Multi-cancer Detection Using Pattern Formation in Drying Body Fluids: A Systematic Review and Meta-Analysis of Diagnostic Test Accuracy Studies.Technology in cancer research & treatmentPooled it
- Relative Humidity Shifts During Evaporation Enhance the Donor Differentiation Potential of Serum and Plasma Dried Droplet Patterns.Molecules (Basel, Switzerland) · 2026Article
- Deep learning applied to analyze patterns from evaporated droplets of Viscum album extracts.Scientific reports · 2022Article
- Evaporation Patterns of Dextran-Poly(Ethylene Glycol) Droplets with Changes in Wettability and Compatibility.Life (Basel, Switzerland) · 2022Article
- Patterns in Dried Droplets to Detect Unfolded BSA.Sensors (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
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Abstract
The quality control of medicines guarantees the effectiveness of treatments for diseases. We explore the use of texture analysis of patterns in dried droplets as a tool to readily detect both impurities and changes in drug concentration. Four types of medicines associated with different routes of administration were analyzed: Methotrexate, Ciprofloxacin, Clonazepam, and Budesonide. We use NaCl and a hot substrate at 63 ∘C to promote aggregate formation and to reduce droplet drying time. Depending on the medicine, optical microscopy reveals different complex aggregates such as circular to oval splatters, fern-like islands, crown shapes, crown needle-like and bump-like patterns as well as dendritic branched and star-like crystals. We use some physical features of the stains (as the stain diameter and superficial area) and gray level co-occurrence matrix (GLCM) to characterize patterns of dried droplets. Finally, we show that structural analysis of stains can achieve 95% accuracy in identifying medicines with 30% water dilution, while it achieves 99% accuracy in detecting drugs with 10% other substances.
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Registered trials
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