Evidence map›Paper›PMID 34208397›Full record

ArticleLife (Basel, Switzerland)2021

Protein Secondary Structure Affects Glycan Clustering in Native Mass Spectrometry.

Hao Yan, Julia Lockhauserbäumer, Gergo Peter Szekeres, Alvaro Mallagaray, Robert Creutznacher, Stefan Taube, Thomas Peters, Kevin Pagel, Charlotte Uetrecht

Open access · goldAbstract read
In one paragraph

Article in Life (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Opening opportunities for KCommunications biology · 2022
    Article
  2. Norovirus-glycan interactions - how strong are they really?Biochemical Society transactions · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Hao YanLeibniz Institute for Experimental Virology (HPI), 20251 Hamburg, Germany.
Julia LockhauserbäumerLeibniz Institute for Experimental Virology (HPI), 20251 Hamburg, Germany.
Gergo Peter SzekeresOrganic Chemistry, Free University Berlin, 14195 Berlin, Germany.ORCID 0000-0002-4597-6264
Alvaro MallagarayCenter of Structural and Cell Biology in Medicine (CSCM), Institute of Chemistry and Metabolomics, University of Lübeck, 23562 Lübeck, Germany.ORCID 0000-0001-5825-4407
Robert CreutznacherCenter of Structural and Cell Biology in Medicine (CSCM), Institute of Chemistry and Metabolomics, University of Lübeck, 23562 Lübeck, Germany.
Stefan TaubeInstitute of Virology, University of Lübeck, 23562 Lübeck, Germany.ORCID 0000-0002-9159-3651
Thomas PetersCenter of Structural and Cell Biology in Medicine (CSCM), Institute of Chemistry and Metabolomics, University of Lübeck, 23562 Lübeck, Germany.
Kevin PagelOrganic Chemistry, Free University Berlin, 14195 Berlin, Germany.
Charlotte UetrechtLeibniz Institute for Experimental Virology (HPI), 20251 Hamburg, Germany.ORCID 0000-0002-1991-7922
University of Lübeck · DELeibniz Institute of Virology (LIV) · DEFritz Haber Institute of the Max Planck Society · DE

Funding

Deutsche Forschungsgemeinschaft FOR 2327 VirocarbHorizon 2020 Framework Programme 899687Leibniz-Gemeinschaft SAW-2014-HPI-4
6 · The paper itself

Abstract

Infection by the humannoroviruses (hNoV), for the vast majority of strains, requires attachment of the viral capsid to histo blood group antigens (HBGAs). The HBGA-binding pocket is formed by dimers of the protruding domain (P dimers) of the capsid protein VP1. Several studies have focused on HBGA binding to P dimers, reporting binding affinities and stoichiometries. However, nuclear magnetic resonance spectroscopy (NMR) and native mass spectrometry (MS) analyses yielded incongruent dissociation constants (K

Indexed as

carbohydrate bindingelectrospray ionizationHBGAion mobilitynative MSnorovirus capsid protein

Identifiers

PMID34208397
PMCPMC8231113
OpenAlexW3170881171

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.