Evidence map›Paper›PMID 34208361›Full record

ArticleDiagnostics (Basel, Switzerland)2021

Deep Learning-Based Post-Processing of Real-Time MRI to Assess and Quantify Dynamic Wrist Movement in Health and Disease.

Karl Ludger Radke, Lena Marie Wollschläger, Sven Nebelung, Daniel Benjamin Abrar, Christoph Schleich, Matthias Boschheidgen, Miriam Frenken, Justus Schock, Dirk Klee, Jens Frahm and 4 more

Open access · goldAbstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Advances in Artificial Intelligence for Wrist Joint Injury Diagnosis.International journal of medical sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Karl Ludger RadkeDepartment of Diagnostic and Interventional Radiology, Medical Faculty, University Dusseldorf, D-40225 Dusseldorf, Germany.ORCID 0000-0003-1095-1283
Lena Marie WollschlägerDepartment of Diagnostic and Interventional Radiology, Medical Faculty, University Dusseldorf, D-40225 Dusseldorf, Germany.ORCID 0000-0002-1159-863X
Sven NebelungDepartment of Diagnostic and Interventional Radiology, Medical Faculty, University Dusseldorf, D-40225 Dusseldorf, Germany.ORCID 0000-0002-5267-9962
Daniel Benjamin AbrarDepartment of Diagnostic and Interventional Radiology, Medical Faculty, University Dusseldorf, D-40225 Dusseldorf, Germany.ORCID 0000-0002-8116-4431
Christoph SchleichDepartment of Diagnostic and Interventional Radiology, Medical Faculty, University Dusseldorf, D-40225 Dusseldorf, Germany.
Matthias BoschheidgenDepartment of Diagnostic and Interventional Radiology, Medical Faculty, University Dusseldorf, D-40225 Dusseldorf, Germany.
Miriam FrenkenDepartment of Diagnostic and Interventional Radiology, Medical Faculty, University Dusseldorf, D-40225 Dusseldorf, Germany.ORCID 0000-0001-5197-6861
Justus SchockDepartment of Diagnostic and Interventional Radiology, Medical Faculty, University Dusseldorf, D-40225 Dusseldorf, Germany.ORCID 0000-0003-0512-3053
Dirk KleeDepartment of Diagnostic and Interventional Radiology, Medical Faculty, University Dusseldorf, D-40225 Dusseldorf, Germany.
Jens FrahmBiomedizinische NMR, Max-Planck Institute for Biophysical Chemistry, D-37077 Goettingen, Germany.ORCID 0000-0002-8279-884X
Gerald AntochDepartment of Diagnostic and Interventional Radiology, Medical Faculty, University Dusseldorf, D-40225 Dusseldorf, Germany.
Simon ThelenDepartment of Orthopaedics and Trauma Surgery, Medical Faculty, University Dusseldorf, D-40225 Dusseldorf, Germany.
Hans-Jörg WittsackDepartment of Diagnostic and Interventional Radiology, Medical Faculty, University Dusseldorf, D-40225 Dusseldorf, Germany.
Anja Müller-LutzDepartment of Diagnostic and Interventional Radiology, Medical Faculty, University Dusseldorf, D-40225 Dusseldorf, Germany.ORCID 0000-0002-7798-5384
Heinrich Heine University Düsseldorf · DEDüsseldorf University Hospital · DEMax Planck Institute for Biophysical Chemistry · DE

Funding

Deutsche Forschungsgemeinschaft NE 2136/3-1
6 · The paper itself

Abstract

While morphologic magnetic resonance imaging (MRI) is the imaging modality of choice for the evaluation of ligamentous wrist injuries, it is merely static and incapable of diagnosing dynamic wrist instability. Based on real-time MRI and algorithm-based image post-processing in terms of convolutional neural networks (CNNs), this study aims to develop and validate an automatic technique to quantify wrist movement. A total of 56 bilateral wrists (28 healthy volunteers) were imaged during continuous and alternating maximum ulnar and radial abduction. Following CNN-based automatic segmentations of carpal bone contours, scapholunate and lunotriquetral gap widths were quantified based on dedicated algorithms and as a function of wrist position. Automatic segmentations were in excellent agreement with manual reference segmentations performed by two radiologists as indicated by Dice similarity coefficients of 0.96 ± 0.02 and consistent and unskewed Bland-Altman plots. Clinical applicability of the framework was assessed in a patient with diagnosed scapholunate ligament injury. Considerable increases in scapholunate gap widths across the range-of-motion were found. In conclusion, the combination of real-time wrist MRI and the present framework provides a powerful diagnostic tool for dynamic assessment of wrist function and, if confirmed in clinical trials, dynamic carpal instability that may elude static assessment using clinical-standard imaging modalities.

Indexed as

carpal instabilitydeep learningdynamic instabilitymagnetic resonance imagingreal-timescapholunate ligament injury

Identifiers

PMID34208361
PMCPMC8231139
OpenAlexW3170429131

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.