Evidence map›Paper›PMID 34208297›Full record

ArticleMolecules (Basel, Switzerland)2021

Biphenylalkoxyamine Derivatives-Histamine H

Dorota Łażewska, Paula Zaręba, Justyna Godyń, Agata Doroz-Płonka, Annika Frank, David Reiner-Link, Marek Bajda, Dorota Stary, Szczepan Mogilski, Agnieszka Olejarz-Maciej and 4 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Benzophenone Derivatives with Histamine HMolecules (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Dorota ŁażewskaDepartment of Technology and Biotechnology of Drugs, Jagiellonian University Medical College, Medyczna Str. 9, 30-688 Kraków, Poland.ORCID 0000-0001-8454-4440
Paula ZarębaDepartment of Physicochemical Drug Analysis, Jagiellonian University Medical College, Medyczna Str. 9, 30-688 Kraków, Poland.
Justyna GodyńDepartment of Physicochemical Drug Analysis, Jagiellonian University Medical College, Medyczna Str. 9, 30-688 Kraków, Poland.ORCID 0000-0002-0295-2772
Agata Doroz-PłonkaDepartment of Technology and Biotechnology of Drugs, Jagiellonian University Medical College, Medyczna Str. 9, 30-688 Kraków, Poland.
Annika FrankInstitute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitätsstr. 1, 40225 Düsseldorf, Germany.
David Reiner-LinkInstitute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitätsstr. 1, 40225 Düsseldorf, Germany.ORCID 0000-0003-1514-2215
Marek BajdaDepartment of Physicochemical Drug Analysis, Jagiellonian University Medical College, Medyczna Str. 9, 30-688 Kraków, Poland.ORCID 0000-0001-6032-0354
Dorota StaryDepartment of Physicochemical Drug Analysis, Jagiellonian University Medical College, Medyczna Str. 9, 30-688 Kraków, Poland.ORCID 0000-0002-8503-9961
Szczepan MogilskiDepartment of Pharmacodynamic, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna Str. 9, 30-688 Kraków, Poland.ORCID 0000-0002-3072-8890
Agnieszka Olejarz-MaciejDepartment of Technology and Biotechnology of Drugs, Jagiellonian University Medical College, Medyczna Str. 9, 30-688 Kraków, Poland.ORCID 0000-0002-1466-0742
Maria KaletaDepartment of Technology and Biotechnology of Drugs, Jagiellonian University Medical College, Medyczna Str. 9, 30-688 Kraków, Poland.
Holger StarkInstitute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitätsstr. 1, 40225 Düsseldorf, Germany.ORCID 0000-0003-3336-1710
Barbara MalawskaDepartment of Physicochemical Drug Analysis, Jagiellonian University Medical College, Medyczna Str. 9, 30-688 Kraków, Poland.
Katarzyna Kieć-KononowiczDepartment of Technology and Biotechnology of Drugs, Jagiellonian University Medical College, Medyczna Str. 9, 30-688 Kraków, Poland.ORCID 0000-0002-6752-7443
Jagiellonian University · PLHeinrich Heine University Düsseldorf · DE

Funding

the National Science Centre, Poland UMO-2016/23/B/NZ7/02327
6 · The paper itself

Abstract

Neurodegenerative diseases, e.g., Alzheimer's disease (AD), are a key health problem in the aging population. The lack of effective therapy and diagnostics does not help to improve this situation. It is thought that ligands influencing multiple but interconnected targets can contribute to a desired pharmacological effect in these complex illnesses. Histamine H

Indexed as

AcetylcholinesteraseAlzheimer DiseaseAminesAnimalsButyrylcholinesteraseCell LineCholinesterase InhibitorsHumansLigandsMaleMiceModels, AnimalMolecular Docking SimulationMolecular StructureMonoamine OxidaseReceptors, Histamine H3AcetylcholinesteraseAminesButyrylcholinesteraseCholinesterase InhibitorsLigandsMonoamine OxidaseReceptors, Histamine H3Alzheimer’s diseasebutyrylcholinesterase inhibitorshistamine H3 receptor ligandsmonoamine oxidase inhibitorsmulti-target ligands

Identifiers

PMID34208297
PMCPMC8231170
OpenAlexW3167374067

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.