Evidence map›Paper›PMID 34208220›Full record

ArticleAntibiotics (Basel, Switzerland)2021

Antibiotic Susceptibility, Virulome, and Clinical Outcomes in European Infants with Bloodstream Infections Caused by Enterobacterales.

Laura Folgori, Domenico Di Carlo, Francesco Comandatore, Aurora Piazza, Adam A Witney, Ilia Bresesti, Yingfen Hsia, Kenneth Laing, Irene Monahan, Julia Bielicki and 5 more

Open access · goldAbstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Emergence of multidrug resistant Enterobacter spp. in Nigeria: a genomic study.World journal of microbiology & biotechnology · 2026
    Article
  3. Article
  4. Macrolide Resistance ofInfection and drug resistance · 2026
    Article
  5. Phenotypic and genome-based characterization ofFrontiers in microbiology · 2026
    Article
  6. Article
  7. Whole Genome Sequencing ofAntibiotics (Basel, Switzerland) · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 3 countries.

Laura FolgoriPaediatric Infectious Disease Research Group, Institute for Infection and Immunity, St George's University of London, Cranmer Terrace, London SW17 0RE, UK.
Domenico Di CarloPaediatric Clinical Research Centre "Romeo and Enrica Invernizzi", Department of Biosciences, University of Milan, Via Giovanni Battista Grassi 74, 20157 Milan, Italy.
Francesco ComandatorePaediatric Clinical Research Centre "Romeo and Enrica Invernizzi", Department of Biosciences, University of Milan, Via Giovanni Battista Grassi 74, 20157 Milan, Italy.
Aurora PiazzaClinical-Surgical, Diagnostic and Pediatric Sciences Department, Unit of Microbiology and Clinical Microbiology, University of Pavia, Corso Str. Nuova 65, 27100 Pavia, Italy.
Adam A WitneyInstitute of Infection and Immunity, St George's University of London, Cranmer Terrace, London SW17 0RE, UK.
Ilia BresestiDepartment of Paediatrics, Vittore Buzzi Children Hospital, University of Milan, Via Lodovico Castelvetro 32, 20154 Milan, Italy.ORCID 0000-0002-6812-7556
Yingfen HsiaPaediatric Infectious Disease Research Group, Institute for Infection and Immunity, St George's University of London, Cranmer Terrace, London SW17 0RE, UK.ORCID 0000-0002-7955-852X
Kenneth LaingInstitute of Infection and Immunity, St George's University of London, Cranmer Terrace, London SW17 0RE, UK.ORCID 0000-0003-1883-3433
Irene MonahanInstitute of Infection and Immunity, St George's University of London, Cranmer Terrace, London SW17 0RE, UK.
Julia BielickiPaediatric Infectious Disease Research Group, Institute for Infection and Immunity, St George's University of London, Cranmer Terrace, London SW17 0RE, UK.
Alessandro AlvaroPaediatric Clinical Research Centre "Romeo and Enrica Invernizzi", Department of Biosciences, University of Milan, Via Giovanni Battista Grassi 74, 20157 Milan, Italy.
Gian Vincenzo ZuccottiDepartment of Paediatrics, Vittore Buzzi Children Hospital, University of Milan, Via Lodovico Castelvetro 32, 20154 Milan, Italy.ORCID 0000-0002-2795-9874
Tim PlancheInstitute of Infection and Immunity, St George's University of London, Cranmer Terrace, London SW17 0RE, UK.
Paul T HeathPaediatric Infectious Disease Research Group, Institute for Infection and Immunity, St George's University of London, Cranmer Terrace, London SW17 0RE, UK.
Mike SharlandPaediatric Infectious Disease Research Group, Institute for Infection and Immunity, St George's University of London, Cranmer Terrace, London SW17 0RE, UK.
St George's, University of London · GBUniversity of Milan · ITQueen's University Belfast · GBUniversity of Pavia · IT

Funding

Penta Foundation na
6 · The paper itself

Abstract

Mortality in neonates with Gram-negative bloodstream infections has remained unacceptably high. Very few data are available on the impact of resistance profiles, virulence factors, appropriateness of empirical treatment and clinical characteristics on patients' mortality. A survival analysis to investigate 28-day mortality probability and predictors was performed including (I) infants <90 days (II) with an available Enterobacterales blood isolate with (III) clinical, treatment and 28-day outcome data. Eighty-seven patients were included. Overall, 299 virulence genes were identified among all the pathogens.

Indexed as

bacteremiadrug resistanceGram-negative bacteriainfantmicrobialmortalitynewbornvirulence factors

Identifiers

PMID34208220
PMCPMC8230887
OpenAlexW3169176269

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.