ArticleMolecules (Basel, Switzerland)2021
Santamarine Shows Anti-Photoaging Properties via Inhibition of MAPK/AP-1 and Stimulation of TGF-β/Smad Signaling in UVA-Irradiated HDFs.
Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Plant-Derived Natural Products: An In-depth Review of Compounds and Potential Applications in Skin Aging.Chinese journal of integrative medicine · 2026Review
- Protein Post-Translational Modifications in UV-Induced Skin Damage.Experimental dermatology · 2026Review
- Promoting collagen synthesis: a viable strategy to combat skin ageing.Journal of enzyme inhibition and medicinal chemistry · 2025Review
- Inhibition of TNF-α-Induced Collagen Degradation and Oxidative Damage byCurrent issues in molecular biology · 2025Article
- Photoaging: Current Concepts on Molecular Mechanisms, Prevention, and Treatment.American journal of clinical dermatology · 2025Review
- Natural Compounds with Beneficial Effects on Skin Collagen Type I and Mechanisms of Their Action.Antioxidants (Basel, Switzerland) · 2025Review
- Recent advances in dermal fibroblast senescence and skin aging: unraveling mechanisms and pioneering therapeutic strategies.Frontiers in pharmacology · 2025Review
- Beneficial effects of proanthocyanidins on skin aging: a review.Frontiers in nutrition · 2025Review
- Screening the active ingredients of plants via molecular docking technology and evaluating their ability to reduce skin photoaging.Biogerontology · 2024Article
- Article
- Marine Bioactive Peptides: Anti-Photoaging Mechanisms and Potential Skin Protective Effects.Current issues in molecular biology · 2024Review
- Regulatory Mechanisms of Natural Active Ingredients and Compounds on Keratinocytes and Fibroblasts in Mitigating Skin Photoaging.Clinical, cosmetic and investigational dermatology · 2024Review
- Inhibitory Effects of Sesquiterpenoids Isolated fromInternational journal of molecular sciences · 2023Article
- The Effects of Flavonol and Flavone Glucuronides fromAntioxidants (Basel, Switzerland) · 2023Article
- Article
- Role of Phytochemicals in Skin PhotoprotectionFrontiers in pharmacology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic UVA exposure results in elevated reactive oxygen species in skin which leads to photoaging characterized as upregulated matrix metalloproteinase (MMP)-1 and loss of collagen. Therefore, natural antioxidants are hailed as promising agents to be utilized against photoaging. In the current study, reynosin and santamarine, two known sesquiterpene lactones isolated from
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.