ArticlePlants (Basel, Switzerland)2021
Safflower Extract Inhibits ADP-Induced Human Platelet Aggregation.
Article in Plants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- Design and optimization of a negative pressure rotary cutting safflower filaments harvesting device.Scientific reports · 2025Article
- Synergistic Innovative Therapies in Dermatology: Integrating Platelet Derivatives, Biomaterials, and Exogenous Bioactive Substances for Enhancing Skin Repair and Regeneration.Drug design, development and therapy · 2025Review
- Pharmacological actions and applications of safflower flavonoids.Frontiers in nutrition · 2025Review
- Investigation into safflower injection as a prophylactic treatment for retinal vein occlusion in a rabbit model.Scientific reports · 2024Article
- Article
- Genome-wide identification and comprehensive analysis of WRKY transcription factor family in safflower during drought stress.Scientific reports · 2023Article
- Elucidation of Phytochemicals Affecting Platelet Responsiveness in Dangguisu-san: Active Ingredient Prediction and Experimental Research Using Network Pharmacology.Plants (Basel, Switzerland) · 2023Article
- Luteolin inhibits GPVI-mediated platelet activation, oxidative stress, and thrombosis.Frontiers in pharmacology · 2023Article
- Is autologous platelet activation the key step in ovarian therapy for fertility recovery and menopause reversal?BioMedicine · 2022Review
- Pharmacological Activities of Safflower Yellow and Its Clinical Applications.Evidence-based complementary and alternative medicine : eCAM · 2022Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Safflower extract is commonly used as a traditional Chinese medicine to promote blood circulation and remove blood stasis. The antioxidant and anticancer properties of safflower extracts have been extensively studied, but their antiaggregative effects have been less analyzed. We found that safflower extract inhibited human platelet aggregation induced by ADP. In addition, we further analyzed several safflower extract compounds, such as hydroxysafflor yellow A, safflower yellow A, and luteolin, which have the same antiaggregative effect. In addition to analyzing the active components of the safflower extract, we also analyzed their roles in the ADP signaling pathways. Safflower extract can affect the activation of downstream conductors of ADP receptors (such as the production of calcium ions and cAMP), thereby affecting the expression of activated glycoproteins on the platelet membrane and inhibiting platelet aggregation. According to the results of this study, the effect of safflower extract on promoting blood circulation and removing blood stasis may be related to its direct inhibition of platelet activation.
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Registered trials
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