ReviewInternational journal of molecular sciences2021
Characterization and Quantification of Selenoprotein P: Challenges to Mass Spectrometry.
Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed.
- Development of a New Method for the Absolute Quantification of Selenoproteins in Chicken Serum by Heteroatom-Tagged Proteomics.Journal of agricultural and food chemistry · 2026Article
- An Alternative UV-Vis Spectrophotometric Method for Accurate Quantification of Total Selenium in Se-Enriched Microbial Biomass.ACS omega · 2025Article
- Selenium Discrepancies in Fetal Bovine Serum: Impact on Cellular Selenoprotein Expression.International journal of molecular sciences · 2024Article
- Selenium speciation studies in cancer patients to evaluate the responses of biomarkers of selenium status to different selenium compounds.Analytical and bioanalytical chemistry · 2024Article
- "Alphabet" Selenoproteins: Their Characteristics and Physiological Roles.International journal of molecular sciences · 2023Review
- Excessive copper impairs intrahepatocyte trafficking and secretion of selenoprotein P.Nature communications · 2023Article
- Effect of Organic Selenium on the Homeostasis of Trace Elements, Lipid Peroxidation, and mRNA Expression of Antioxidant Proteins in Mouse Organs.International journal of molecular sciences · 2023Article
- Selenoprotein P concentrations and risk of progression from mild cognitive impairment to dementia.Scientific reports · 2023Article
- Selenoprotein P Concentrations in the Cerebrospinal Fluid and Serum of Individuals Affected by Amyotrophic Lateral Sclerosis, Mild Cognitive Impairment and Alzheimer's Dementia.International journal of molecular sciences · 2022Article
- Selenoprotein: Potential Player in Redox Regulation inAntioxidants (Basel, Switzerland) · 2022Article
- Selenium Metabolism and Biosynthesis of Selenoproteins in the Human Body.Biochemistry. Biokhimiia · 2022Review
- Assessment of Iodine and Selenium Nutritional Status in Women of Reproductive Age in Latvia.Medicina (Kaunas, Lithuania) · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Selenoprotein P (SELENOP) is an emerging marker of the nutritional status of selenium and of various diseases, however, its chemical characteristics still need to be investigated and methods for its accurate quantitation improved. SELENOP is unique among selenoproteins, as it contains multiple genetically encoded SeCys residues, whereas all the other characterized selenoproteins contain just one. SELENOP occurs in the form of multiple isoforms, truncated species and post-translationally modified variants which are relatively poorly characterized. The accurate quantification of SELENOP is contingent on the availability of specific primary standards and reference methods. Before recombinant SELENOP becomes available to be used as a primary standard, careful investigation of the characteristics of the SELENOP measured by electrospray MS and strict control of the recoveries at the various steps of the analytical procedures are strongly recommended. This review critically discusses the state-of-the-art of analytical approaches to the characterization and quantification of SELENOP. While immunoassays remain the standard for the determination of human and animal health status, because of their speed and simplicity, mass spectrometry techniques offer many attractive and complementary features that are highlighted and critically evaluated.
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