Evidence map›Paper›PMID 34208077›Full record

ArticleGenes2021

The Association of ATG16L1 Variations with Clinical Phenotypes of Adult-Onset Still's Disease.

Wei-Ting Hung, Shuen-Iu Hung, Yi-Ming Chen, Chia-Wei Hsieh, Hsin-Hua Chen, Kuo-Tung Tang, Der-Yuan Chen, Tsuo-Hung Lan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Wei-Ting HungInstitute of Clinical Medicine, National Yang-Ming Chiao Tung University, Taipei 11221, Taiwan.
Shuen-Iu HungCancer Vaccine and Immune Cell Therapy Core Laboratory, Chang Gung Immunology Consortium, Chang Gung Memorial Hospital, Linkou, Taoyuan 33305, Taiwan.ORCID 0000-0001-6531-5538
Yi-Ming ChenDepartment of Medical Research, Taichung Veterans General Hospital, Taichung 40705, Taiwan.ORCID 0000-0001-7593-3065
Chia-Wei HsiehRong Hsing Research Center for Translational Medicine & Ph.D. Program in Translational Medicine, National Chung Hsing University, Taichung 40227, Taiwan.
Hsin-Hua ChenRong Hsing Research Center for Translational Medicine & Ph.D. Program in Translational Medicine, National Chung Hsing University, Taichung 40227, Taiwan.ORCID 0000-0002-7304-4587
Kuo-Tung TangSchool of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan.ORCID 0000-0002-5468-1329
Der-Yuan ChenTranslational Medicine Laboratory, Rheumatology and Immunology Center, China Medical University Hospital, Taichung 40447, Taiwan.
Tsuo-Hung LanInstitute of Clinical Medicine, National Yang-Ming Chiao Tung University, Taipei 11221, Taiwan.ORCID 0000-0002-2796-1026
National Yang Ming Chiao Tung University · TWNational Chung Hsing University · TWChang Gung Memorial Hospital · TWChina Medical University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adult-onset Still's disease (AOSD) is a rare autoinflammatory disease, which has elevated autophagosome levels regulated by autophagy-related gene (ATG) expression. We investigated the associations of ATG polymorphisms with AOSD susceptibility, clinical manifestations, and disease course. The six-candidate single-nucleotide polymorphisms (SNPs) involved in autophagy were genotyped using direct sequencing on samples from 129 AOSD patients and 129 healthy participants. The differentially expressed gene products were quantified using PCR and ELISA. Significant linkage disequilibrium was noted in three SNPs of autophagy-related 16-like 1 (

Indexed as

PhenotypePolymorphism, Single NucleotideAdultAutophagosomesAutophagy-Related ProteinsCells, CulturedCytokinesFemaleHaplotypesHumansMaleMicrotubule-Associated ProteinsMiddle AgedSkinStill's Disease, Adult-OnsetATG16L1 protein, humanAutophagy-Related ProteinsCytokinesMAP1LC3B protein, humanMicrotubule-Associated Proteinsadult-onset Still’s diseaseATG16L1autophagyhaplotypesingle-nucleotide polymorphism

Identifiers

PMID34208077
PMCPMC8230810
OpenAlexW3167327751

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.