Evidence map›Paper›PMID 34208049›Full record

ArticleAntioxidants (Basel, Switzerland)2021

Specificity of Human Sulfiredoxin for Reductant and Peroxiredoxin Oligomeric State.

Tom E Forshaw, Julie A Reisz, Kimberly J Nelson, Rajesh Gumpena, J Reed Lawson, Thomas J Jönsson, Hanzhi Wu, Jill E Clodfelter, Lynnette C Johnson, Cristina M Furdui and 1 more

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Tom E ForshawDepartment of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157, USA.ORCID 0000-0001-9266-3925
Julie A ReiszDepartment of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157, USA.
Kimberly J NelsonCenter for Structural Biology, Department of Biochemistry, Wake Forest School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157, USA.
Rajesh GumpenaCenter for Structural Biology, Department of Biochemistry, Wake Forest School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157, USA.
J Reed LawsonCenter for Structural Biology, Department of Biochemistry, Wake Forest School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157, USA.
Thomas J JönssonCenter for Structural Biology, Department of Biochemistry, Wake Forest School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157, USA.
Hanzhi WuDepartment of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157, USA.
Jill E ClodfelterCenter for Structural Biology, Department of Biochemistry, Wake Forest School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157, USA.
Lynnette C JohnsonCenter for Structural Biology, Department of Biochemistry, Wake Forest School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157, USA.
Cristina M FurduiDepartment of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157, USA.
W Todd LowtherCenter for Structural Biology, Department of Biochemistry, Wake Forest School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157, USA.ORCID 0000-0002-0246-1295
Wake Forest University · US

Funding

Tumor Tissue CoreP30CA012197 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Ruben A. Mesa · 1985 to 2026
$55.4M
Model-based Prediction of Redox-Modulated Responses to Cancer TreatmentsU01CA215848 · NCI · GEORGIA INSTITUTE OF TECHNOLOGY · PI FURDUI, CRISTINA MARIA, KEMP, MELISSA LAMBETH · 2017 to 2021
$3.6M
Structures &Redox Chemistry in Sulfinic Acid ReductionR01GM072866 · NIGMS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI LOWTHER, W TODD · 2005 to 2014
$2.6M
New Oxidation-Sensing Probes to Evaluate Mitochondrial Dysfunction in Lung InjuryR33ES025645 · NIEHS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI FURDUI, CRISTINA MARIA, KING, S BRUCE · 2017 to 2019
$1.5M
NCI NIH HHS P30 CA012197NCI NIH HHS U01 CA215848NIEHS NIH HHS R33 ES025645NIGMS NIH HHS R01 GM072866
6 · The paper itself

Abstract

Human peroxiredoxins (Prx) are a family of antioxidant enzymes involved in a myriad of cellular functions and diseases. During the reaction with peroxides (e.g., H

Indexed as

glutathionehydrogen sulfideperoxiredoxinredoxsulfiredoxinthiols

Identifiers

PMID34208049
PMCPMC8230665
OpenAlexW3170570526

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.