Evidence map›Paper›PMID 34207958›Full record

ArticleViruses2021

An Examination of the Long-Term Neurodevelopmental Impact of Prenatal Zika Virus Infection in a Rat Model Using a High Resolution, Longitudinal MRI Approach.

Rita T Patel, Brennan M Gallamoza, Praveen Kulkarni, Morgan L Sherer, Nicole A Haas, Elise Lemanski, Ibrahim Malik, Khan Hekmatyar, Mark S Parcells, Jaclyn M Schwarz

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Rita T PatelDepartment of Psychological and Brain Sciences, University of Delaware, Newark, DE 19716, USA.ORCID 0000-0001-7702-1289
Brennan M GallamozaDepartment of Psychological and Brain Sciences, University of Delaware, Newark, DE 19716, USA.
Praveen KulkarniCenter for Translational Neuroimaging, Department of Psychology, Northeastern University, Boston, MA 02115, USA.ORCID 0000-0002-8876-4544
Morgan L ShererW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Nicole A HaasDepartment of Psychological and Brain Sciences, University of Delaware, Newark, DE 19716, USA.
Elise LemanskiDepartment of Psychological and Brain Sciences, University of Delaware, Newark, DE 19716, USA.
Ibrahim MalikCenter for Biomedical and Brain Imaging, Department of Psychological and Brain Sciences, University of Delaware, Newark, DE 19716, USA.
Khan HekmatyarCenter for Biomedical and Brain Imaging, Department of Psychological and Brain Sciences, University of Delaware, Newark, DE 19716, USA.
Mark S ParcellsDepartment of Animal and Food Sciences, University of Delaware, Newark, DE 19716, USA.ORCID 0000-0003-0311-3820
Jaclyn M SchwarzDepartment of Psychological and Brain Sciences, University of Delaware, Newark, DE 19716, USA.
University of Delaware · USJohns Hopkins University · USNortheastern University · US

Funding

Updated confocal microscope in the Imaging Core facility to support biomedical researchP20GM103653 · NIGMS · DELAWARE STATE UNIVERSITY · PI HARRINGTON, MELISSA A · 2012 to 2022
$22.7M
Long-term impact of prenatal ZIKV infection on neurogenesisR21HD096309 · NICHD · UNIVERSITY OF DELAWARE · PI SCHWARZ, JACLYN MARIE · 2019 to 2020
$431k
NICHD NIH HHS R21 HD096309NIGMS NIH HHS P20 GM103653
6 · The paper itself

Abstract

Since Zika virus (ZIKV) first emerged as a public health concern in 2015, our ability to identify and track the long-term neurological sequelae of prenatal Zika virus (ZIKV) infection in humans has been limited. Our lab has developed a rat model of maternal ZIKV infection with associated vertical transmission to the fetus that results in significant brain malformations in the neonatal offspring. Here, we use this model in conjunction with longitudinal magnetic resonance imaging (MRI) to expand our understanding of the long-term neurological consequences of prenatal ZIKV infection in order to identify characteristic neurodevelopmental changes and track them across time. We exploited both manual and automated atlas-based segmentation of MR images in order to identify long-term structural changes within the developing rat brain following inoculation. The paradigm involved scanning three cohorts of male and female rats that were prenatally inoculated with 10

Indexed as

Infectious Disease Transmission, VerticalAnimalsDisease Models, AnimalFemaleMagnetic Resonance ImagingNeurodevelopmental DisordersNeuroimagingPregnancyPregnancy Complications, InfectiousRatsZika VirusZika Virus Infectioncongenital infectionMRIneurodevelopmentneuroimagingpregnancyZika virus (ZIKV)

Identifiers

PMID34207958
PMCPMC8230645
OpenAlexW3171568214

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.