ArticlePharmaceuticals (Basel, Switzerland)2021
Optimization of Novel Naproxen-Loaded Chitosan/Carrageenan Nanocarrier-Based Gel for Topical Delivery: Ex Vivo, Histopathological, and In Vivo Evaluation.
Article in Pharmaceuticals (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 48 citations in OpenAlex.
- Cellulose and Its Derivatives in Drug Delivery: Recent Advances and Applications.Pharmaceutics · 2026Review
- Ionic Liquid-Enabled Drug Delivery Systems: Benefits, Limitations, and Future Perspectives.Pharmaceutics · 2026Review
- Development and evaluation of chitosan-xanthan gum-based controlled release nanoparticles of mebeverine hydrochloride for targeted IBS therapy: in silico, in vitro, and in vivo investigations.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2025Article
- Production and Characterization of Nanoparticulate Polyelectrolyte Complexes of Chitosan-Catechol, Ulvan, and Hyaluronic Acid.ACS omega · 2025Article
- Penetration of Microplastics and Nanoparticles Through Skin: Effects of Size, Shape, and Surface Chemistry.Journal of xenobiotics · 2024Review
- Optimizing lornoxicam-loaded poly(lactic-co-glycolic acid) and (polyethylene glycol) nanoparticles for transdermal delivery:Nanomedicine (London, England) · 2024Article
- Biopolymer-Based Hydrogel Incorporated with Naproxen Sodium and Lidocaine Hydrochloride for Controlled Drug Delivery.Polymers · 2024Article
- Reduction in Pathogenic Biofilms by the Photoactive Composite of Bacterial Cellulose and Nanochitosan Dots under Blue and Green Light.Journal of functional biomaterials · 2024Article
- Transdermal Microneedle-Mediated Delivery of Rasagiline Nanoparticles.Archives of Razi Institute · 2023Article
- Chitosan Hydrogels Cross-Linked with Trimesic Acid for the Delivery of 5-Fluorouracil in Cancer Therapy.Pharmaceutics · 2023Article
- New Ferulic Acid and Amino Acid Derivatives with Increased Cosmeceutical and Pharmaceutical Potential.Pharmaceutics · 2022Article
- Photo-Phytotherapeutic Gel Composed ofPharmaceutics · 2022Article
- Solubilization and Controlled Release Strategy of Poorly Water-Soluble Drugs.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Natural polysaccharide-based biodegradable polymeric platforms for transdermal drug delivery system: a critical analysis.Drug delivery and translational research · 2022Review
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Naproxen (NAP) is commonly used for pain, inflammation, and stiffness associated with arthritis. However, systemic administration is linked with several gastrointestinal tract (GIT) side effects. The present work aims to prepare and evaluate NAP nanoparticulate shells of chitosan (CS) and carrageenan (CRG) loaded into a Carbopol 940 (Ca-940) gel system with unique features of sustained drug delivery as well as improved permeation through a topical route. Moreover, this study aims to evaluate its ex vivo, histopathological, and in vivo anti-inflammatory activity in albino Wistar rats. The percentage of ex vivo drug permeation patterns in the optimized formulation (No) was higher (88.66%) than the control gel (36.195%). Oral toxicity studies of developed nanoparticles in albino rabbits showed that the NAP-loaded CS/CRG are non-toxic and, upon histopathological evaluation, no sign of incompatibility was observed compared to the control group. A In Vivo study showed that the optimized gel formulation (No) was more effective than the control gel (Nc) in treating arthritis-associated inflammation. The sustained permeation and the absence of skin irritation make this novel NAP nanoparticle-loaded gel based on CS/CRG a suitable drug delivery system for topical application and has the potential for improved patient compliance and reduced GIT-related side effects in arthritis.
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