ReviewViruses2021
The Nature of Immune Responses to Influenza Vaccination in High-Risk Populations.
Review in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- A systematic review and meta-analysis on the association between PMFrontiers in epidemiology · 2025Pooled it
- A study of booster dose influenza vaccination responses compared to standard dose in lupus patients: an open-labeled, randomized controlled study.Clinical and experimental medicine · 2025Trial
- Maternal influenza vaccination during pregnancy and risk of autism spectrum disorder in the offspring.JCPP advances · 2026Article
- Association Between Immunosuppressive Cell Populations and Immune Response to Influenza Vaccination in Younger and Older Adults.Vaccines · 2026Article
- Influenza Vaccination Responses in Disabled Stroke Patients: A Single-Center Prospective Observational Study.Annals of clinical and translational neurology · 2026Article
- Age-related thymic involution: Mechanistic insights and rejuvenating approaches to restore immune function.Science advances · 2026Review
- Teaching an old vector new tricks: the surprising versatility of AAV vaccines.Journal of virology · 2025Review
- Understanding and improving vaccine efficacy in older adults.Nature aging · 2025Review
- Structural characterization of influenza group 1 chimeric hemagglutinins as broad vaccine immunogens.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Impact of lactobacillus probiotics on vaccine response in diabetic rats: modulation of inflammatory cytokines.American journal of clinical and experimental immunology · 2025Article
- Immunogenicity of Inactivated H5 Avian Influenza Vaccine Used in Commercial Laying Pullet in Tehran Province, Iran.Archives of Razi Institute · 2024Article
- Immunogenicity, Safety, and Efficacy of Influenza Vaccine in T2DM and T2DM with Chronic Kidney Disease.Vaccines · 2024Article
- Analysis of the Immune Response by Standardized Whole-Blood Stimulation with Metabolism Modulation.Phenomics (Cham, Switzerland) · 2024Article
- Immunizing hearts: exploring the vaccination frontier in heart failure management.Annals of medicine and surgery (2012) · 2024Review
- The Impact of Obesity on the Host-Pathogen Interaction with Influenza Viruses - Novel Insights: Narrative Review.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Review
- The uncharted territory of host-pathogen interaction in tuberculosis.Frontiers in immunology · 2024Review
- Nutrition, Immune Function, and Infectious Disease in Military Personnel: A Narrative Review.Nutrients · 2023Review
- Pleiotropic Effects of Influenza Vaccination.Vaccines · 2023Review
- Proteomics analysis of methionine enkephalin upregulated macrophages against infection by the influenza-A virus.Proteome science · 2023Article
- Antiviral Approaches against Influenza Virus.Clinical microbiology reviews · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The current pandemic has brought a renewed appreciation for the critical importance of vaccines for the promotion of both individual and public health. Influenza vaccines have been our primary tool for infection control to prevent seasonal epidemics and pandemics such as the 2009 H1N1 influenza A virus pandemic. Certain high-risk populations, including the elderly, people with obesity, and individuals with comorbidities such as type 2 diabetes mellitus, are more susceptible to increased disease severity and decreased vaccine efficacy. High-risk populations have unique microenvironments and immune responses that contribute to increased vulnerability for influenza infections. This review focuses on these differences as we investigate the variations in immune responses to influenza vaccination. In order to develop better influenza vaccines, it is critical to understand how to improve responses in our ever-growing high-risk populations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.