ArticleViruses2021
Goose Nephritic Astrovirus Infection of Goslings Induces Lymphocyte Apoptosis, Reticular Fiber Destruction, and CD8 T-Cell Depletion in Spleen Tissue.
Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Isolation, identification and phylogenetic analysis of a novel goose astrovirus 2 strain.Poultry science · 2026Article
- Viperin suppresses goose astrovirus type 2 replication through inhibition of viral RdRP activity.Veterinary research · 2026Article
- Splenic transcriptomic profiling reveals innate immune responses and RIG-I-like receptor signaling in goslings infected with goose astrovirus.Frontiers in veterinary science · 2026Article
- Goose Astrovirus Type 2 Causes Intestinal Injury and Disrupts Homeostasis in Goslings.Veterinary sciences · 2025Article
- Pseudorabies virus infection induces lymphocyte depletion associated with cellular apoptosis and endoplasmic reticulum stress in the mouse spleen.BMC veterinary research · 2025Article
- Review
- Effects and potential pathways of goose astrovirus infection on gosling hepatic lipid metabolism.Frontiers in microbiology · 2025Article
- Molecular characterization of a virulent goose astrovirus genotype-2 with high mortality in vitro and in vivo.Poultry science · 2024Article
- Apoptosis, inflammatory and innate immune responses induced by infection with a novel goose astrovirus in goose embryonic kidney cells.Frontiers in cellular and infection microbiology · 2024Article
- Infection and innate immune mechanism of goose astrovirus.Frontiers in microbiology · 2023Review
- A Review of the Emerging Poultry Visceral Gout Disease Linked to Avian Astrovirus Infection.International journal of molecular sciences · 2022Review
- A Review of Emerging Goose Astrovirus Causing Gout.BioMed research international · 2022Review
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The emergence of a novel goose nephritic astrovirus (GNAstV) has caused economic losses to the Chinese goose industry. High viral load is found in the spleen of goslings infected with GNAstV, but pathological injuries to the spleen due to GNAstV are largely unknown. In this study, 50 two-day-old goslings were infected orally with GNAstV, and 50 goslings were treated with PBS as control. Spleens were collected at different times following infection to assess damage. GNAstV infection caused visceral gout and urate deposition in joints, and resulted in 16% mortality. GNAstV was found in the lymphocytes and macrophages within the spleen. Lymphocyte loss, especially around the white pulp, and destruction and decline in the number of reticular fibers was observed in GNAstV-infected goslings. Moreover, in GNAstV-infected goslings, ultrahistopathological examination found that splenic lymphocytes exhibited condensed chromatin and apoptotic bodies, and reticular cells displayed damage to plasma membrane integrity and swollen mitochondria. Furthermore, TUNEL staining confirmed apoptosis of lymphocytes, and the mRNA levels of Fas and FasL were significantly increased in the GNAstV-infected goslings. In addition, GNAstV infection reduced the number and protein expression of CD8. In conclusion, GNAstV infection causes lymphocyte depletion, reticular cell necrosis, reticular fiber destruction, lymphocyte apoptosis, and reduction in CD8 levels, which contribute to spleen injury.
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