Evidence map›Paper›PMID 34207725›Full record

ArticleSensors (Basel, Switzerland)2021

Inkjet-Printed and Electroplated 3D Electrodes for Recording Extracellular Signals in Cell Culture.

Leroy Grob, Philipp Rinklin, Sabine Zips, Dirk Mayer, Sabrina Weidlich, Korkut Terkan, Lennart J K Weiß, Nouran Adly, Andreas Offenhäusser, Bernhard Wolfrum

Open access · goldAbstract read
In one paragraph

Article in Sensors (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Leroy GrobNeuroelectronics, Department of Electrical and Computer Engineering, MSB, MSRM, Technical University of Munich, Boltzmannstraße 11, 85748 Garching, Germany.ORCID 0000-0002-2696-7725
Philipp RinklinNeuroelectronics, Department of Electrical and Computer Engineering, MSB, MSRM, Technical University of Munich, Boltzmannstraße 11, 85748 Garching, Germany.ORCID 0000-0003-1063-8342
Sabine ZipsNeuroelectronics, Department of Electrical and Computer Engineering, MSB, MSRM, Technical University of Munich, Boltzmannstraße 11, 85748 Garching, Germany.
Dirk MayerInstitute of Biological Information Processing (IBI-3), Forschungszentrum Jülich GmbH, 52425 Jülich, Germany.ORCID 0000-0003-1296-8265
Sabrina WeidlichInstitute of Biological Information Processing (IBI-3), Forschungszentrum Jülich GmbH, 52425 Jülich, Germany.
Korkut TerkanNeuroelectronics, Department of Electrical and Computer Engineering, MSB, MSRM, Technical University of Munich, Boltzmannstraße 11, 85748 Garching, Germany.
Lennart J K WeißNeuroelectronics, Department of Electrical and Computer Engineering, MSB, MSRM, Technical University of Munich, Boltzmannstraße 11, 85748 Garching, Germany.ORCID 0000-0002-6943-737X
Nouran AdlyNeuroelectronics, Department of Electrical and Computer Engineering, MSB, MSRM, Technical University of Munich, Boltzmannstraße 11, 85748 Garching, Germany.
Andreas OffenhäusserInstitute of Biological Information Processing (IBI-3), Forschungszentrum Jülich GmbH, 52425 Jülich, Germany.ORCID 0000-0001-6143-2702
Bernhard WolfrumNeuroelectronics, Department of Electrical and Computer Engineering, MSB, MSRM, Technical University of Munich, Boltzmannstraße 11, 85748 Garching, Germany.
Technical University of Munich · DEForschungszentrum Jülich · DE

Funding

Deutsche Forschungsgemeinschaft 393439476
6 · The paper itself

Abstract

Recent investigations into cardiac or nervous tissues call for systems that are able to electrically record in 3D as opposed to 2D. Typically, challenging microfabrication steps are required to produce 3D microelectrode arrays capable of recording at the desired position within the tissue of interest. As an alternative, additive manufacturing is becoming a versatile platform for rapidly prototyping novel sensors with flexible geometric design. In this work, 3D MEAs for cell-culture applications were fabricated using a piezoelectric inkjet printer. The aspect ratio and height of the printed 3D electrodes were user-defined by adjusting the number of deposited droplets of silver nanoparticle ink along with a continuous printing method and an appropriate drop-to-drop delay. The Ag 3D MEAs were later electroplated with Au and Pt in order to reduce leakage of potentially cytotoxic silver ions into the cellular medium. The functionality of the array was confirmed using impedance spectroscopy, cyclic voltammetry, and recordings of extracellular potentials from cardiomyocyte-like HL-1 cells.

Indexed as

Metal NanoparticlesCell Culture TechniquesDielectric SpectroscopyMicroelectrodesSilverSilver3D electrodesbioelectronicscyclic voltammetryelectrodepositionimpedance spectroscopyinkjet printing

Identifiers

PMID34207725
PMCPMC8229631
OpenAlexW3172242883

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.