Evidence map›Paper›PMID 34207618›Full record

ArticleCells2021

Approaches to Potentiated Neuroprotective Treatment in the Rodent Model of Ischemic Optic Neuropathy.

Zara Mehrabian, Yan Guo, Neil R Miller, Amanda D Henderson, Steven Roth, Steven L Bernstein

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Zara MehrabianDepartment of Ophthalmology and Visual Sciences, School of Medicine, University of Maryland at Baltimore (UMB), 10 S. Pine St., MSTF Room 5-77B, Baltimore, MD 21201, USA.
Yan GuoDepartment of Ophthalmology and Visual Sciences, School of Medicine, University of Maryland at Baltimore (UMB), 10 S. Pine St., MSTF Room 5-77B, Baltimore, MD 21201, USA.
Neil R MillerDivision of Neuro-Ophthalmology, Wilmer Eye Institute, School of Medicine, Johns Hopkins University, 600 N. Wolfe St., Wilmer 233, Baltimore, MD 21287, USA.
Amanda D HendersonDivision of Neuro-Ophthalmology, Wilmer Eye Institute, School of Medicine, Johns Hopkins University, 600 N. Wolfe St., Wilmer 233, Baltimore, MD 21287, USA.
Steven RothDepartment of Anesthesiology, College of Medicine, University of Illinois, Chicago, IL 20212, USA.ORCID 0000-0002-4955-9855
Steven L BernsteinDepartment of Ophthalmology and Visual Sciences, School of Medicine, University of Maryland at Baltimore (UMB), 10 S. Pine St., MSTF Room 5-77B, Baltimore, MD 21201, USA.ORCID 0000-0001-7758-0136
University of Maryland, Baltimore · USJohns Hopkins University · USUniversity of Illinois Urbana-Champaign · US

Funding

The Role of Adenosine in Retinal IschemiaR01EY010343 · NEI · UNIVERSITY OF CHICAGO · PI ROTH, STEVEN · 1994 to 2014
$4.8M
Mechanisms of Optic Nerve Stroke NeuroprotectionR01EY015304 · NEI · UNIVERSITY OF MARYLAND BALTIMORE · PI BERNSTEIN, STEVEN L · 2004 to 2018
$4.7M
Novel Cell Free Therapy for GlaucomaR21EY028690 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI ROTH, STEVEN · 2019 to 2020
$477k
Hillside Foundation 2015-01NEI NIH HHS R01 EY010343NEI NIH HHS R01 EY015304NEI NIH HHS R21 EY028690
6 · The paper itself

Abstract

Nonarteritic anterior ischemic optic neuropathy (NAION) commonly causes sudden optic nerve (ON)-related vision loss. The rodent NAION model (rAION) closely resembles NAION in presentation and physiological responses. We identified early rAION-associated optic nerve head (ONH) inflammatory gene expression responses and the anti-inflammatory prostaglandin PGJ

Indexed as

BenzodioxolesMeloxicamNeuroprotective AgentsPiperidinesProstaglandin AntagonistsAnimalsDisease Models, AnimalMaleOptic Neuropathy, IschemicRatsRats, Sprague-DawleyRetinal Ganglion Cells1,1,1,3,3,3-hexafluoropropan-2-yl 4-(bis(benzo(d)(1,3)dioxol-5-yl)(hydroxy)methyl)piperidine-1-carboxylateBenzodioxolesMeloxicamNeuroprotective AgentsPiperidinesProstaglandin Antagonistsanimal modelgene expressioninflammationischemianeuroprotectionnonarteritic anterior ischemic optic neuropathy (NAION)optic nervePGJ2prostaglandinretinal ganglion cellrodent

Identifiers

PMID34207618
PMCPMC8228425
OpenAlexW3171467468

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.