Evidence map›Paper›PMID 34207552›Full record

ReviewMaterials (Basel, Switzerland)2021

Recent Advances in the Development of Antimicrobial and Antifouling Biocompatible Materials for Dental Applications.

Poornima Ramburrun, Nadine A Pringle, Admire Dube, Razia Z Adam, Sarah D'Souza, Marique Aucamp

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Materials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
11.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 105 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Poornima RamburrunSchool of Pharmacy, Faculty of Natural Sciences, University of the Western Cape, Cape Town 7535, South Africa.ORCID 0000-0003-3385-155X
Nadine A PringleSchool of Pharmacy, Faculty of Natural Sciences, University of the Western Cape, Cape Town 7535, South Africa.
Admire DubeSchool of Pharmacy, Faculty of Natural Sciences, University of the Western Cape, Cape Town 7535, South Africa.
Razia Z AdamDepartment of Restorative Dentistry, Faculty of Dentistry, University of the Western Cape, Cape Town 7505, South Africa.ORCID 0000-0002-2645-9878
Sarah D'SouzaSchool of Pharmacy, Faculty of Natural Sciences, University of the Western Cape, Cape Town 7535, South Africa.ORCID 0000-0002-1750-4964
Marique AucampSchool of Pharmacy, Faculty of Natural Sciences, University of the Western Cape, Cape Town 7535, South Africa.ORCID 0000-0003-2561-4458
University of the Western Cape · ZA

Funding

National Research Foundation of South Africa 129890
6 · The paper itself

Abstract

The risk of secondary bacterial infections resulting from dental procedures has driven the design of antimicrobial and antifouling dental materials to curb pathogenic microbial growth, biofilm formation and subsequent oral and dental diseases. Studies have investigated approaches based primarily on contact-killing or release-killing materials. These materials are designed for addition into dental resins, adhesives and fillings or as immobilized coatings on tooth surfaces, titanium implants and dental prosthetics. This review discusses the recent developments in the different classes of biomaterials for antimicrobial and antifouling dental applications: polymeric drug-releasing materials, polymeric and metallic nanoparticles, polymeric biocides and antimicrobial peptides. With modifications to improve cytotoxicity and mechanical properties, contact-killing and anti-adhesion materials show potential for incorporation into dental materials for long-term clinical use as opposed to short-lived antimicrobial release-based coatings. However, extended durations of biocompatibility testing, and adjustment of essential biomaterial features to enhance material longevity in the oral cavity require further investigations to confirm suitability and safety of these materials in the clinical setting. The continuous exposure of dental restorative and regenerative materials to pathogenic microbes necessitates the implementation of antimicrobial and antifouling materials to either replace antibiotics or improve its rational use, especially in the day and age of the ever-increasing problem of antimicrobial resistance.

Indexed as

antimicrobial and antifouling materialsbiofilmsdental restorative materialsperiodontitispolymersrecurrent caries

Identifiers

PMID34207552
PMCPMC8229368
OpenAlexW3169593969

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.