ArticleLife (Basel, Switzerland)2021
Abnormal Intracranial Pulse Pressure Amplitude Despite Normalized Static Intracranial Pressure in Idiopathic Intracranial Hypertension Refractory to Conservative Medical Therapy.
Article in Life (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 22 citations in OpenAlex.
- Exploring the temporal statistical relationship between commercial cerebral near-infrared spectroscopy signals and intracranial pressure in traumatic brain injury.Intensive care medicine experimental · 2026Article
- The impact of human brain geometry on the transport of an intrathecal tracer.Fluids and barriers of the CNS · 2026Article
- Continuous Intracranial Pressure Monitoring in Children with 'Benign' External Hydrocephalus.Journal of clinical medicine · 2025Article
- A method for measuring first glymphatic influx of a cerebrospinal fluid tracer in the human brain.Frontiers in neuroscience · 2025Article
- CSF hyperdynamics in rats mimicking the obesity and androgen excess characteristic of patients with idiopathic intracranial hypertension.Fluids and barriers of the CNS · 2024Article
- Modelling idiopathic intracranial hypertension in rats: contributions of high fat diet and testosterone to intracranial pressure and cerebrospinal fluid production.Fluids and barriers of the CNS · 2023Article
- Interpretation of telemetric intracranial pressure recordings in people with idiopathic intracranial hypertension after shunt implantation.Acta neurochirurgica · 2023Article
- A Neuro-Ophthalmologist's Guide to Advances in Intracranial Pressure Measurements.Eye and brain · 2023Review
- Noninvasive Estimation of Pulsatile and Static Intracranial Pressure by Optical Coherence Tomography.Translational vision science & technology · 2022Article
- A New Perspective on the Pathophysiology of Idiopathic Intracranial Hypertension: Role of the Glia-Neuro-Vascular Interface.Frontiers in molecular neuroscience · 2022Article
- Angiographic Pulse Wave Coherence in the Human Brain.Frontiers in bioengineering and biotechnology · 2022Article
- Evolving Evidence in Idiopathic Intracranial Hypertension.Life (Basel, Switzerland) · 2021Article
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1 author at 1 institution in 1 country.
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Abstract
Idiopathic intracranial hypertension (IIH) incorporates symptoms and signs of increased intracranial pressure (ICP) and is diagnosed by increased lumbar cerebrospinal fluid pressure. However, our knowledge about the characteristics of ICP abnormality, e.g., changes in pulsatile versus static ICP, remains scarce. This study questioned how overnight pulsatile ICP (mean ICP wave amplitude, MWA) associates with static ICP (mean ICP) in IIH patients who were refractory to conservative medical treatment. The material included 80 consecutive IIH patients undergoing ICP monitoring prior to shunt, as part of work-up for failed conservative medical therapy. In this group, the overnight mean ICP was normalized in 52/80 patients, but with abnormal overnight MWA in 45 of the 52 patients. Even though there was a positive correlation between MWA and mean ICP at group level and within individual ICP recordings, the levels of MWA were abnormal in a high proportion of patients despite normalized mean ICP. Taken together, the present results disclosed lasting abnormal pulsatile ICP despite normalized static ICP in IIH patients refractory to conservative medical therapy, which may reflect the underlying pathophysiology. It is tentatively suggested that abnormal pulsatile ICP in IIH may reflect alterations at the glia-neurovascular interface, resulting in impaired astrocytic pulsation absorber mechanisms.
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