Evidence map›Paper›PMID 34207459›Full record

ArticleCancers2021

Contemporary Analysis of Electronic Frailty Measurement in Older Adults with Multiple Myeloma Treated in the National US Veterans Affairs Healthcare System.

Clark DuMontier, Nathanael R Fillmore, Cenk Yildirim, David Cheng, Jennifer La, Ariela R Orkaby, Brian Charest, Diana Cirstea, Sarvari Yellapragada, John Michael Gaziano and 5 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 1 country.

Clark DuMontierNew England Geriatrics Research, Education and Clinical Center, VA Boston Healthcare System, Boston, MA 02130, USA.
Nathanael R FillmoreHarvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-8058-3423
Cenk YildirimMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), Boston, MA 02130, USA.
David ChengMassachusetts General Hospital, Boston, MA 02114, USA.
Jennifer LaMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), Boston, MA 02130, USA.
Ariela R OrkabyNew England Geriatrics Research, Education and Clinical Center, VA Boston Healthcare System, Boston, MA 02130, USA.
Brian CharestMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), Boston, MA 02130, USA.
Diana CirsteaDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Sarvari YellapragadaMichael E. Debakey VA Medical Center and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.
John Michael GazianoDivision of Aging, Brigham and Women's Hospital, Boston, MA 02115, USA.
Nhan DoVA Boston CSP Center, Boston, MA 02130, USA.
Mary T BrophyVA Boston CSP Center, Boston, MA 02130, USA.
Dae H KimMarcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA 02131, USA.
Nikhil C MunshiHarvard Medical School, Boston, MA 02115, USA.
Jane A DriverNew England Geriatrics Research, Education and Clinical Center, VA Boston Healthcare System, Boston, MA 02130, USA.
Brigham and Women's Hospital · USVA Boston Healthcare System · USBoston University · USHarvard University · USBeth Israel Deaconess Medical Center · USDana-Farber Cancer Institute · USMassachusetts General Hospital · USMichael E. DeBakey VA Medical Center · US

Funding

Trageting the Multiple Myeloma EpigenomeP50CA100707 · NCI · DANA-FARBER CANCER INSTITUTE · PI ANDERSON, KENNETH C. · 2003 to 2023
$45.0M
Targeting Genomic Instability and Evolution in MyelomaP01CA155258 · NCI · DANA-FARBER CANCER INST · PI Nikhil C. Munshi · 2011 to 2026
$32.5M
Preparing For What Is Next With Aducanumab In Real World SettingsR33AG057806 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Christopher Barrett Bowling, Ana Roman Quinones · 2018 to 2026
$9.0M
Translational Researchin Aging Trainnig ProgramT32AG023480 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI LIPSITZ, LEWIS · 2004 to 2024
$7.6M
Frailty, Statins, and Cardiovascular Disease Burden in Older AdultsR03AG060169 · NIA · HARVARD MEDICAL SCHOOL · PI ORKABY, ARIELA R · 2018 to 2019
$193k
Integration of Geriatric Measures Alongside Disease-Based Measures to Advance Precision Oncology for Older Veterans with Multiple MyelomaIK2CX002218 · VA · VA BOSTON HEALTH CARE SYSTEM · PI DUMONTIER, CLARK WILLIAM · 2021 to 2024
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Statins for Primary Prevention of Cardiovascular Disease and FrailtyIK2CX001800 · VA · VA BOSTON HEALTH CARE SYSTEM · PI ORKABY, ARIELA R · 2019 to 2023
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MOLECULAR MANIPULATION TO ENHANCE ANTI-MYELOMA RESPONSEI01BX001584 · VA · VA BOSTON HEALTH CARE SYSTEM · PI MUNSHI, NIKHIL C. · 2013 to 2025
–
BLRD VA I01 BX001584CSRD VA IK2 CX001800CSRD VA IK2 CX002218NCI NIH HHS P0115525807NCI NIH HHS P01 CA155258NCI NIH HHS P50100707NCI NIH HHS P50 CA100707NIA NIH HHS R03 AG060169NIA NIH HHS R03AG060169NIA NIH HHS R33 AG057806NIA NIH HHS R33AG057806NIA NIH HHS T32 AG023480NIA NIH HHS T32AG023480U.S. Department of Veterans Affairs I01BX001584U.S. Department of Veterans Affairs IK2CX001800U.S. Department of Veterans Affairs IK2CX002218VA Health Services Research and Development Service, VA Information Resource Center Project Numbers SDR 02-237 and 98-004VA Office of Research and Development, Cooperative Studies Program N/A
6 · The paper itself

Abstract

Electronic frailty indices based on data from administrative claims and electronic health records can be used to estimate frailty in large populations of older adults with cancer where direct frailty measures are lacking. The objective of this study was to use the electronic Veterans Affairs Frailty Index (VA-FI-10)-developed and validated to measure frailty in the national United States (US) VA Healthcare System-to estimate the prevalence and impact of frailty in older US veterans newly treated for multiple myeloma (MM) with contemporary therapies. We designed a retrospective cohort study of 4924 transplant-ineligible veterans aged ≥ 65 years initiating MM therapy within VA from 2004 to 2017. Initial MM therapy was measured using inpatient and outpatient treatment codes from pharmacy data in the VA Corporate Data Warehouse. In total, 3477 veterans (70.6%) were classified as frail (VA-FI-10 > 0.2), with 1510 (30.7%) mildly frail (VA-FI-10 > 0.2-0.3), 1105 (22.4%) moderately frail (VA-FI-10 > 0.3-0.4), and 862 (17.5%) severely frail (VA-FI-10 > 0.4). Survival and time to hospitalization decreased with increasing VA-FI-10 severity (log-rank

Indexed as

frailtyfrailty indexgeriatric assessmentmultiple myeloma

Identifiers

PMID34207459
PMCPMC8233717
OpenAlexW3175166505

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.