Fabrication of an Electrochemical Aptasensor Composed of Multifunctional DNA Three-Way Junction on Au Microgap Electrode for Interferon Gamma Detection in Human Serum.

Seungwoo Noh, Jinmyeong Kim, Chulhwan Park, Junhong Min, Taek Lee

Open access · goldAbstract read

In one paragraph

Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

0.9field-weighted citation impact, top 27% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 15 citations in OpenAlex.

Electrochemical Aptasensing for Lifestyle and Chronic Disease Management.Current medicinal chemistry · 2023
Review
Recent Advances in Aptasensor for Cytokine Detection: A Review.Sensors (Basel, Switzerland) · 2021
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Seungwoo NohDepartment of Chemical Engineering, Kwangwoon University, Seoul 01897, Korea.

Jinmyeong KimDepartment of Chemical Engineering, Kwangwoon University, Seoul 01897, Korea.

Chulhwan ParkDepartment of Chemical Engineering, Kwangwoon University, Seoul 01897, Korea.ORCID 0000-0003-1148-7881

Junhong MinSchool of Integrative Engineering, Chung-Ang University, Seoul 06974, Korea.

Taek LeeDepartment of Chemical Engineering, Kwangwoon University, Seoul 01897, Korea.

Kwangwoon University · KRChung-Ang University · KR

Funding

This work was supported by the National Research Foundation of Korea(NRF) granat funded by the Korea government(MSIT) ( No.2021R1C1C1005583)

6 · The paper itself

Abstract

Interferon gamma (IFN-γ) is an important cytokine with antiviral, antibacterial, and immunosuppressive properties. It has been used as a biomarker for the early detection of several diseases, including cancer, human immunodeficiency virus (HIV), tuberculosis, and paratuberculosis. In this study, we developed an electrochemical biosensor composed of multifunctional DNA 3WJ to detect IFN-γ level with high sensitivity. Each multifunctional triple-stranded aptamer (MF-3WJ) was designed to have an IFN-γ aptamer sequence, anchoring region (thiol group), and 4C-C (cytosine-cytosine) mismatch sequence (signal generation), which could introduce silver ions. To generate the electrochemical signal, four Ag

Indexed as

aptasensorbiomarkerelectrochemical biosensorIFN-γ detection

Identifiers

PMID34207431

DOI10.3390/biomedicines9060692

PMCPMC8233955

OpenAlexW3175116379

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.