Evidence map›Paper›PMID 34207354›Full record

ArticleViruses2021

Modular Lentiviral Vectors for Highly Efficient Transgene Expression in Resting Immune Cells.

Christina Fichter, Anupriya Aggarwal, Andrew Kam Ho Wong, Samantha McAllery, Vennila Mathivanan, Bailey Hao, Hugh MacRae, Melissa J Churchill, Paul R Gorry, Michael Roche and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Christina FichterThe Kirby Institute for Infection and Immunity in Society, The University of New South Wales, Sydney, NSW 2052, Australia.ORCID 0000-0003-0365-087X
Anupriya AggarwalThe Kirby Institute for Infection and Immunity in Society, The University of New South Wales, Sydney, NSW 2052, Australia.ORCID 0000-0001-8678-0519
Andrew Kam Ho WongThe Kirby Institute for Infection and Immunity in Society, The University of New South Wales, Sydney, NSW 2052, Australia.
Samantha McAlleryThe Kirby Institute for Infection and Immunity in Society, The University of New South Wales, Sydney, NSW 2052, Australia.
Vennila MathivananThe Kirby Institute for Infection and Immunity in Society, The University of New South Wales, Sydney, NSW 2052, Australia.
Bailey HaoThe Kirby Institute for Infection and Immunity in Society, The University of New South Wales, Sydney, NSW 2052, Australia.
Hugh MacRaeThe Kirby Institute for Infection and Immunity in Society, The University of New South Wales, Sydney, NSW 2052, Australia.
Melissa J ChurchillSTEM College, RMIT University, Melbourne, VIC 3000, Australia.ORCID 0000-0001-5510-7954
Paul R GorrySTEM College, RMIT University, Melbourne, VIC 3000, Australia.
Michael RocheDepartment of Infectious Diseases, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia.
Lachlan R GrayViiV Healthcare, Abbotsford, VIC 3067, Australia.ORCID 0000-0002-9894-1049
Stuart TurvilleThe Kirby Institute for Infection and Immunity in Society, The University of New South Wales, Sydney, NSW 2052, Australia.
UNSW Sydney · AURMIT University · AUThe University of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gene/cell therapies are promising strategies for the many presently incurable diseases. A key step in this process is the efficient delivery of genes and gene-editing enzymes to many cell types that may be resistant to lentiviral vector transduction. Herein we describe tuning of a lentiviral gene therapy platform to focus on genetic modifications of resting CD4

Indexed as

Gene ExpressionGene Transfer TechniquesResting Phase, Cell CycleTransgenesAnimalsCD4-Positive T-LymphocytesFlow CytometryGenetic VectorsGenotypeHumansLentivirusT-LymphocytesTransduction, GeneticCRISPR-Cas9gene therapylentiviral vectorsMS2-LVLPsresting T cellsvpx

Identifiers

PMID34207354
PMCPMC8235771
OpenAlexW3176970621

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.